In the dynamic field of organic chemistry, the availability of reliable and versatile intermediates is fundamental to innovation and production. Tert-Butyl 5-Bromovalerate, identified by its CAS number 88987-42-2, is a prime example of such an essential compound. Its unique chemical structure and reactivity make it a cornerstone for numerous synthetic pathways, particularly in the creation of pharmaceuticals, agrochemicals, and specialized reagents used in biological research.

Understanding the Chemistry of Tert-Butyl 5-Bromovalerate

Tert-Butyl 5-Bromovalerate, also known as tert-butyl 5-bromopentanoate, is characterized by a five-carbon chain terminating in a bromide group and protected at the carboxylic acid terminus by a tert-butyl ester. This structure grants it specific reactivity:

  • Alkylating Agent: The primary bromide is an excellent leaving group, readily participating in nucleophilic substitution reactions. This allows chemists to attach the five-carbon chain to various nucleophiles, such as amines, alcohols, or thiols.
  • Protected Carboxylic Acid: The tert-butyl ester is stable under many reaction conditions but can be selectively removed (deprotected) under acidic conditions, revealing the carboxylic acid for further transformations like amide formation or reduction.
  • Chirality Potential: While the parent molecule is achiral, its incorporation into larger structures can lead to the creation of chiral centers.

Physically, Tert-Butyl 5-Bromovalerate is typically a liquid, appearing as colorless to light yellow, with a boiling point of 93°C at 1.6 Torr and a density of approximately 1.223 g/cm³. These properties are important for handling and processing in laboratory and industrial settings.

Synthetic Utility and Applications

The value of Tert-Butyl 5-Bromovalerate lies in its broad applicability in chemical synthesis:

  • Pharmaceutical Intermediates: It is extensively used in the synthesis of complex organic molecules that form the basis of many drug therapies. Its structure can be elaborated to create pharmacologically active compounds.
  • Agrochemicals: In the agricultural sector, it serves as a building block for synthesizing new pesticides, herbicides, and plant growth regulators, contributing to improved crop yields and protection.
  • Biotechnology and Immunoassays: It is a key reagent in preparing haptens, which are critical for generating antibodies used in diagnostics, such as ELISA kits for pesticide detection or disease markers.
  • Materials Science: Its versatile reactivity can be leveraged in the development of specialized polymers or functional materials.

Sourcing and Procurement Advice

For professionals looking to buy Tert-Butyl 5-Bromovalerate (CAS 88987-42-2), sourcing from reliable manufacturers is crucial. China is a significant global supplier of such chemical intermediates, often offering competitive pricing and high-purity products. When selecting a supplier, consider these factors:

  • Purity and Quality: Always verify product specifications and request a Certificate of Analysis (CoA) to confirm purity (e.g., 99%).
  • Manufacturer Reputation: Choose suppliers with established track records in chemical manufacturing and export.
  • Bulk Availability and Pricing: For industrial use, securing a steady supply at favorable prices is key. Obtain quotes for bulk quantities.
  • Delivery and Logistics: Understand lead times and shipping options to ensure timely project execution.

Procurement managers should actively seek out manufacturers through reputable online platforms or direct contact to request quotes and samples. This proactive approach ensures access to essential materials like Tert-Butyl 5-Bromovalerate for ongoing research and production needs.

In summary, Tert-Butyl 5-Bromovalerate (CAS 88987-42-2) is a pivotal intermediate whose versatility fuels innovation across critical industries. By focusing on quality sourcing from trusted manufacturers, organizations can effectively leverage this compound in their synthetic endeavors.