In the demanding field of pharmaceutical research and development, securing high-purity chemical intermediates is fundamental to success. Tetraacetylribofuranose (CAS 13035-61-5) is a prime example of such a critical compound, serving as a versatile building block for a wide array of therapeutic agents. This article outlines its importance, key applications, and provides guidance for procurement specialists on how to effectively buy this essential intermediate from reliable sources.

The Importance of Tetraacetylribofuranose in Pharmaceutical Synthesis

Tetraacetylribofuranose is a protected form of ribofuranose, a naturally occurring sugar. The acetylation of its hydroxyl groups enhances its stability and solubility in organic solvents, making it highly amenable to complex chemical transformations. This makes it an ideal starting material for synthesizing nucleosides, nucleotides, and other complex biomolecules. Its chemical formula is C13H18O9, and it is typically supplied as a white crystalline powder with a high purity (often >98%). These characteristics are vital for ensuring consistent reaction outcomes in pharmaceutical manufacturing.

Key Applications Driving Demand:

  • Nucleoside and Nucleotide Synthesis: This intermediate is fundamental for creating the building blocks of DNA and RNA. Its utility extends to the synthesis of modified nucleosides with potential antiviral and anticancer properties. Researchers looking to purchase this compound can rely on its established role in these synthetic pathways.
  • Antiviral Drug Manufacturing: Tetraacetylribofuranose is a crucial intermediate in the production of antiviral medications, notably Ribavirin. The consistent availability of this intermediate from a dependable manufacturer is essential for ensuring the uninterrupted supply of these vital medicines.
  • Drug Discovery and Development: Its structure allows medicinal chemists to incorporate modified ribose moieties into new drug candidates, exploring treatments for various diseases, including viral infections and cancer. Obtaining a competitive quote for research quantities is a common starting point.
  • Glycobiology Research: The compound is also used in academic and industrial research to study carbohydrate structures and their roles in biological processes.

Choosing a Reliable Supplier

When selecting a supplier for Tetraacetylribofuranose, especially from regions like China, where many chemical manufacturers are located, it is important to consider:

  • Quality Control: Always prioritize suppliers who provide detailed Certificates of Analysis (CoA) to verify purity and specifications.
  • Manufacturing Expertise: A good manufacturer will have a strong track record in producing pharmaceutical intermediates with consistent quality.
  • Supply Chain Management: Ensure the supplier can guarantee reliable delivery schedules to support your production timelines.
  • Pricing: Obtaining quotes from multiple reliable vendors is crucial for competitive pricing.

By carefully evaluating these factors, pharmaceutical professionals can secure a consistent and high-quality supply of Tetraacetylribofuranose, enabling the efficient development and production of life-saving drugs. If you are looking to buy this essential intermediate, partnering with an experienced supplier is key.