NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing comprehensive information about the chemical compounds we supply. This article delves into the fundamental properties and synthesis of 4-(Aminomethyl)tetrahydro-2H-pyran (CAS 130290-79-8), a key intermediate in various chemical and pharmaceutical processes.

Understanding the physical and chemical characteristics of a compound is crucial for its effective utilization. 4-(Aminomethyl)tetrahydro-2H-pyran is described as a clear, colorless to light yellow liquid. Its molecular formula is C6H13NO, with a molecular weight of approximately 115.17 g/mol. Key physical properties reported include a boiling point around 75-76 °C and a density of approximately 0.942 g/cm³. The refractive index typically falls within the range of 1.4630-1.4670. These properties inform handling, storage, and reaction conditions.

Chemically, the compound features a stable tetrahydropyran ring, a six-membered saturated heterocycle containing one oxygen atom. Attached to the ring at the 4-position is an aminomethyl group (-CH2NH2). This primary amine functionality is highly reactive and serves as the primary site for chemical modifications and derivative formation. The presence of the ether linkage within the ring also influences its polarity and reactivity.

The synthesis of 4-(Aminomethyl)tetrahydro-2H-pyran typically involves several well-established chemical routes. One common method is the reduction of 4-cyanotetrahydro-2H-pyran. This reduction can be achieved through various means, including catalytic hydrogenation using catalysts such as Raney nickel or palladium, or through the use of reducing agents like lithium aluminum hydride. For instance, a process might involve reacting 4-cyanotetrahydropyran with ammonia-methanol solution in the presence of activated Raney nickel under hydrogen pressure and controlled temperature. Following the reaction, purification through distillation yields the desired product.

Another viable synthesis pathway is the reductive amination of tetrahydro-4H-pyran-4-one. This process typically involves reacting the ketone with an ammonia source (like ammonium formate) and a reducing agent. The reaction conditions are often mild, making it an attractive option. The choice of synthesis route often depends on the availability of starting materials, desired purity levels, scalability, and cost-effectiveness.

The successful synthesis and subsequent purification of 4-(Aminomethyl)tetrahydro-2H-pyran are critical for its application in demanding fields like pharmaceutical research. NINGBO INNO PHARMCHEM CO.,LTD. ensures that the compounds we supply meet stringent quality standards, providing researchers with reliable materials for their synthetic endeavors. Access to detailed synthesis information and high-quality products empowers scientific progress.