For chemists and pharmaceutical formulators, a thorough understanding of the chemical intermediates they use is fundamental. Today, we focus on N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, identified by its CAS number 918504-27-5. This complex organic molecule is a cornerstone in the synthesis of Vemurafenib, a critical drug in targeted cancer therapy. As a manufacturer specializing in high-quality pharmaceutical intermediates, we provide detailed insights into this compound's profile.

The chemical name itself, N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, hints at its intricate structure, featuring a pyrrolo[2,3-b]pyridine core, a bromine substituent, a difluorophenyl group, and a propane-1-sulfonamide moiety. Its molecular formula is C17H14BrF2N3O3S, and it possesses a molecular weight of approximately 458.27700 g/mol. This structure is specifically designed to facilitate key reaction steps in the Vemurafenib synthesis pathway.

From a practical standpoint, our manufacturing process ensures that this intermediate is supplied as a white to yellow crystalline powder. This physical form is generally stable and easy to handle in laboratory and production environments. The assay of our product consistently meets or exceeds ≥98.0%, a critical parameter for any pharmaceutical intermediate where high purity is directly linked to the efficiency and success of subsequent reactions.

As a manufacturer and supplier, we are committed to providing comprehensive specifications for our products. Researchers and procurement professionals looking to buy CAS 918504-27-5 will find that our data sheets clearly outline all essential details, from chemical identity to purity levels. This transparency is vital for building trust and ensuring that our clients can confidently integrate our intermediates into their complex synthetic routes.

The role of this specific sulfonamide derivative in the synthesis of Vemurafenib cannot be overstated. Vemurafenib is a potent inhibitor of the BRAF V600E mutation, a common driver in several cancers, including melanoma. The precise construction of this molecule relies on intermediates like ours, which carry the necessary structural elements in a highly pure form. Our ability to produce this compound in bulk, typically packaged in 25 kg drums, allows us to support both developmental research and large-scale manufacturing requirements.

For those in the pharmaceutical industry seeking reliable partners for their chemical supply needs, we offer a combination of advanced synthesis capabilities, stringent quality control, and competitive pricing. If your research or production demands N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, we encourage you to contact us. As a dedicated manufacturer in China, we are well-positioned to be your trusted supplier for this essential pharmaceutical intermediate.