For chemists engaged in advanced organic synthesis, understanding the reactivity and synthetic utility of key intermediates is paramount. 3,4-Dimethylthiophenol (CAS 18800-53-8) is a significant compound, frequently utilized as a building block in pharmaceutical and fine chemical manufacturing. This article explores the chemical characteristics that make it so valuable for synthesis and guides researchers on how to procure it effectively.

Chemical Structure and Properties of 3,4-Dimethylthiophenol

3,4-Dimethylthiophenol, also known as 3,4-Xylenethiol, possesses a distinct molecular structure: a benzene ring substituted with methyl groups at the 3 and 4 positions, and a thiol (-SH) group. This arrangement results in a compound with the molecular formula C8H10S and a molecular weight of approximately 138.23 g/mol. Its characteristic boiling point is around 218°C, and it is often supplied as a white powder with high purity, frequently specified as ≥99%. These properties are critical for its effective use in controlled chemical reactions. For synthesis chemists, knowing the CAS number (18800-53-8) is essential for accurate identification and ordering.

Reactivity and Synthetic Utility

The thiol group (-SH) is the primary reactive center in 3,4-Dimethylthiophenol, making it a versatile nucleophile and a precursor for various sulfur-containing functional groups:

  • Nucleophilic Reactions: The sulfur atom, with its lone pairs of electrons, readily participates in nucleophilic substitution reactions, allowing for alkylation or acylation to form thioethers or thioesters.
  • Oxidation Reactions: Thiols can be oxidized to disulfides, sulfinic acids, or sulfonic acids, providing pathways to different functional group transformations.
  • Metal Complexation: Sulfur-containing compounds often exhibit good coordination chemistry with various metal ions, which can be exploited in catalysis or materials science.
  • Aromatic Substitution: While the thiol group is the primary site of reactivity, the aromatic ring itself can undergo electrophilic aromatic substitution, though the directing effects of the methyl and thiol groups would need to be considered.

These reactive properties make it an attractive intermediate for chemists aiming to buy 3,4-dimethylthiophenol for specific synthesis goals, whether in drug discovery or the creation of novel organic materials.

Sourcing High-Purity Intermediates

For effective synthesis, the purity of starting materials is non-negotiable. When looking to purchase 3,4-dimethylthiophenol, engaging with a reputable chemical manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. is highly recommended. As a direct manufacturer, we ensure that our product meets stringent quality standards. We can provide the necessary documentation, including Certificates of Analysis, to confirm the purity and specifications of the 3,4-Dimethylthiophenol you require. Understanding the 3,4-dimethylthiophenol price from a reliable source ensures that your research and production budgets are managed effectively.

By partnering with experienced chemical manufacturers and suppliers, researchers and production teams can ensure they have access to the high-quality intermediates needed for successful synthetic outcomes. Contact NINGBO INNO PHARMCHEM CO.,LTD. to discuss your needs for 3,4-Dimethylthiophenol (CAS 18800-53-8) and to receive a quote for this essential chemical building block.