For pharmaceutical manufacturers and researchers, the efficient synthesis of Active Pharmaceutical Ingredients (APIs) hinges on the quality and availability of key intermediates. One such critical component is 1-Methylazepan-4-one Hydrochloride (CAS No. 19869-42-2). This compound serves as an indispensable building block in the production of Azelastine Hydrochloride, a widely used antihistamine. Understanding its properties and sourcing it from a reputable manufacturer is paramount for ensuring product efficacy and regulatory compliance.

Azelastine Hydrochloride is a second-generation H1 antagonist prescribed for the treatment of allergic rhinitis and conjunctivitis. Its therapeutic success is directly linked to the purity and integrity of its precursor materials. 1-Methylazepan-4-one Hydrochloride, with its specific chemical structure, provides the necessary framework for constructing the final Azelastine molecule. When seeking to buy this intermediate, procurement managers and R&D scientists prioritize products with detailed specifications, including high assay percentages and minimal impurity levels. These factors directly impact the yield and purity of the synthesized API, influencing overall production costs and patient safety.

The chemical properties of 1-Methylazepan-4-one Hydrochloride are well-documented. Typically appearing as a yellow-brown powder, its specifications often include an assay of ≥95.0%, with strict controls on single impurities (≤1.5%) and total impurities (≤5.0%). These parameters are crucial for pharmaceutical applications, where even minor contaminants can affect drug stability, safety, and regulatory approval. Therefore, selecting a supplier that can consistently deliver material meeting these stringent requirements is a strategic decision for any pharmaceutical company.

Sourcing 1-Methylazepan-4-one Hydrochloride from a reliable supplier in China offers significant advantages, including competitive price points and access to a broad manufacturing network. However, it is essential to partner with a company that demonstrates a commitment to quality control and provides comprehensive technical documentation. This ensures that the intermediate meets international pharmacopeial standards and supports your Abbreviated New Drug Applications (ANDA) or other regulatory filings. Investigating a manufacturer's track record for consistency, supply chain reliability, and customer service is just as important as the product's specifications themselves.

For those looking to secure a consistent and high-quality supply of 1-Methylazepan-4-one Hydrochloride, exploring options for bulk purchase is advisable. This not only helps in optimizing costs but also in ensuring uninterrupted production of Azelastine Hydrochloride. Engaging with experienced chemical providers allows for inquiries about lead times, packaging options (such as 25 kg drums), and storage recommendations, ensuring the material arrives and is stored under optimal conditions. Ultimately, the careful selection and procurement of this vital intermediate are foundational steps towards successful and compliant pharmaceutical manufacturing.