At Ningbo INNO Pharmchem Co., Ltd., we are dedicated to advancing the field of chemical synthesis by providing high-quality intermediates that form the backbone of life-changing medications. One such critical compound is 2-Bromo-5-hydroxybenzaldehyde (CAS: 2973-80-0), a versatile organic molecule that plays a pivotal role in the pharmaceutical industry. Its unique chemical structure and reactivity make it an indispensable building block for a range of therapeutic agents.

The most prominent application of 2-Bromo-5-hydroxybenzaldehyde is its use as a key intermediate in the synthesis of Crisaborole. Crisaborole, marketed under the brand name Eucrisa, is a topical non-steroidal phosphodiesterase-4 (PDE4) inhibitor. It has been a breakthrough treatment for inflammatory skin conditions such as atopic dermatitis and is also being explored for other dermatological indications. The efficient and reliable supply of high-purity 2-Bromo-5-hydroxybenzaldehyde is therefore directly linked to the availability of this important medication.

Beyond Crisaborole, this compound serves as a precursor in the development of other significant pharmaceutical agents. Researchers utilize its reactive bromine and hydroxyl groups to synthesize molecules with potential as inhibitors of BCL-XL, a protein involved in cell survival, and as suppressors of cancer cell growth. This highlights the compound's broad utility in drug discovery and development, particularly in areas of oncology and inflammation.

Understanding the synthesis of 2-Bromo-5-hydroxybenzaldehyde is crucial for ensuring consistent quality and supply. Typically, it involves the controlled bromination of 3-hydroxybenzaldehyde. Manufacturers like those in China are at the forefront of producing this intermediate at scale, leveraging advanced techniques to meet stringent purity requirements, often exceeding 98%. These capabilities are essential for pharmaceutical companies requiring reliable API synthesis building blocks.

The demand for such specialized pharmaceutical intermediates is substantial, and the market is influenced by factors such as patent regulations and the need for consistent quality. Sourcing from reputable manufacturers ensures compliance and reliability. At Ningbo INNO Pharmchem Co., Ltd., we understand these demands and are committed to providing 2-Bromo-5-hydroxybenzaldehyde that meets the highest standards for drug development, supporting researchers and pharmaceutical companies in their pursuit of innovative treatments.

For those seeking to purchase 2-Bromo-5-hydroxybenzaldehyde or explore its potential in novel drug synthesis, partnering with experienced suppliers is key. We offer comprehensive support, from custom synthesis services to ensuring timely delivery, empowering your research and manufacturing endeavors.