At Ningbo INNO Pharmchem Co., Ltd., we are committed to providing comprehensive information about the chemical intermediates we supply, ensuring our clients have a deep understanding of their properties and synthesis. Today, we focus on 2-Bromo-5-hydroxybenzaldehyde (CAS: 2973-80-0), a compound critical to many pharmaceutical applications.

The synthesis of 2-Bromo-5-hydroxybenzaldehyde typically begins with 3-hydroxybenzaldehyde. A common method involves the direct bromination of 3-hydroxybenzaldehyde using bromine in a suitable solvent, such as dichloromethane. The reaction conditions, including temperature control and the rate of bromine addition, are carefully managed to ensure regioselectivity and yield. After the reaction, the product is usually purified through filtration and drying, yielding a solid product with a characteristic appearance.

Physico-chemical properties are crucial for determining the suitability and handling of any chemical compound. 2-Bromo-5-hydroxybenzaldehyde presents as a solid, typically appearing as a white to gray to brown powder. Its melting point is reported to be in the range of 130-135°C, indicating its stability under moderate thermal conditions. The density is approximately 1.737 g/cm³, and its solubility in common organic solvents like chloroform, dichloromethane, and ethyl acetate makes it amenable to various reaction and purification procedures. These properties are essential for its successful integration into complex pharmaceutical synthesis pathways.

The purity of 2-Bromo-5-hydroxybenzaldehyde is a critical factor, especially when used as a pharmaceutical intermediate. Manufacturers strive for purity levels exceeding 98%, often verified by analytical techniques like HPLC and GC-MS. This high purity ensures that downstream reactions proceed efficiently and that the final active pharmaceutical ingredients (APIs) meet stringent regulatory standards.

Understanding these synthesis routes and properties is key for chemical engineers and researchers. At Ningbo INNO Pharmchem Co., Ltd., we work with manufacturers who adhere to strict quality control protocols, ensuring that every batch of 2-Bromo-5-hydroxybenzaldehyde meets the required specifications. This dedication to quality underpins our role in supporting the advancement of pharmaceutical science and the production of vital medicines.