The Crucial Role of Boc-L-Hydroxyproline in Modern Peptide Synthesis
In the intricate world of biochemistry and pharmaceuticals, the precision of chemical synthesis is paramount. Among the vast array of building blocks, protected amino acids play a pivotal role, and Boc-L-Hydroxyproline stands out as a particularly valuable compound. Its CAS number, 13726-69-7, signifies a specific, high-quality intermediate widely sought after by researchers and manufacturers alike. As a leading manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this essential chemical, understanding its profound impact on scientific advancement.
Boc-L-Hydroxyproline is a protected derivative of the non-proteinogenic amino acid hydroxyproline. The 'Boc' group, or tert-butoxycarbonyl, serves as a crucial protecting group for the amine functionality. This protection is vital in peptide synthesis, preventing unwanted side reactions and ensuring that peptide bonds form specifically between the desired amino acid residues. The 'L' designation refers to the specific stereochemical configuration, which is essential for biological activity in the resulting peptides. The 'trans-4-hydroxy' aspect highlights the specific position and orientation of the hydroxyl group on the proline ring, a feature that imparts unique properties and functionalities to the synthesized peptides.
The primary application of Boc-L-Hydroxyproline lies in solid-phase peptide synthesis (SPPS). This technique, pioneered by Bruce Merrifield, allows for the sequential addition of amino acids to a solid support. The Boc protecting group is easily removed under acidic conditions, typically using trifluoroacetic acid (TFA), revealing a free amine group ready for the next coupling reaction. This process, when executed with high-purity intermediates like Boc-L-Hydroxyproline, leads to peptides with defined sequences and desired biological activities. The efficiency and reliability of SPPS have made it a cornerstone in the production of peptides for therapeutic, diagnostic, and research purposes.
Furthermore, Boc-L-Hydroxyproline is not merely a simple amino acid derivative; it is an advanced pharmaceutical intermediate. Its incorporation into peptide chains can significantly influence the conformation, stability, and biological activity of the final peptide. This makes it particularly useful in the development of peptide-based drugs and therapeutics. For instance, it has been identified as an intermediate in the synthesis of Fosinopril-d5 Sodium Salt, a labeled analogue of an angiotensin-converting enzyme (ACE) inhibitor. This highlights its direct relevance in the field of medicinal chemistry and drug development, where precise molecular structures are critical for efficacy.
The demand for high-quality peptide synthesis reagents and pharmaceutical intermediates continues to grow. NINGBO INNO PHARMCHEM CO.,LTD. is committed to meeting this demand by providing consistently pure and reliable products. Our dedication to quality ensures that researchers can confidently use our Boc-L-Hydroxyproline in their most demanding applications, whether it's for synthesizing complex peptides, developing novel drug candidates, or exploring new frontiers in biomaterials. By choosing NINGBO INNO PHARMCHEM CO.,LTD. as your supplier, you are partnering with a company that prioritizes scientific progress through superior chemical manufacturing.
In conclusion, Boc-L-Hydroxyproline (CAS: 13726-69-7) is an indispensable compound for anyone involved in peptide synthesis and pharmaceutical research. Its unique chemical properties, coupled with high purity, make it a preferred choice for a wide range of applications. Trust NINGBO INNO PHARMCHEM CO.,LTD. to provide the quality intermediates you need to drive innovation and achieve your research goals. Explore the possibilities that high-quality Boc-L-Hydroxyproline can unlock for your next project.
Perspectives & Insights
Core Pioneer 24
“This technique, pioneered by Bruce Merrifield, allows for the sequential addition of amino acids to a solid support.”
Silicon Explorer X
“The Boc protecting group is easily removed under acidic conditions, typically using trifluoroacetic acid (TFA), revealing a free amine group ready for the next coupling reaction.”
Quantum Catalyst AI
“This process, when executed with high-purity intermediates like Boc-L-Hydroxyproline, leads to peptides with defined sequences and desired biological activities.”