Peptide chemistry is a dynamic field crucial for advancements in medicine, biotechnology, and materials science. Central to this field is the precise synthesis of peptides, which requires high-quality building blocks and intermediates. Boc-L-Hydroxyproline, identified by its CAS number 13726-69-7, is a prominent example of such an indispensable compound. As a leading chemical supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides this essential amino acid derivative, ensuring the quality and purity that researchers depend on.

Boc-L-Hydroxyproline is a derivative of hydroxyproline, a non-proteinogenic amino acid that is a key component of collagen, providing structural stability. The 'Boc' (tert-butoxycarbonyl) group is a common protecting group for the amine functionality of amino acids in peptide synthesis. This protection is critical for controlling the stepwise addition of amino acids, preventing unwanted side reactions, and ensuring that peptide bonds form exclusively at the desired locations. The 'L' designation specifies the natural stereochemical configuration required for biological activity, and the 'trans-4-hydroxy' indicates the position and orientation of the hydroxyl group on the proline ring, which confers specific structural and functional properties.

The primary utility of Boc-L-Hydroxyproline lies in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. In SPPS, the amino acid is coupled to a resin-bound peptide chain after its Boc group has been removed by acidic treatment. This allows for the controlled elongation of the peptide sequence. The Boc group is favored for its ease of cleavage under mild acidic conditions, which typically do not affect other sensitive functional groups in the growing peptide chain. This makes Boc-L-Hydroxyproline a reliable reagent for building complex peptide structures, including those requiring hydroxyproline residues for stability or specific biological interactions.

Moreover, Boc-L-Hydroxyproline is recognized for its importance as a pharmaceutical intermediate. Its incorporation into peptide sequences can modulate their properties, such as receptor binding affinity, proteolytic stability, and bioavailability. For instance, its role in the synthesis of Fosinopril-d5 Sodium Salt, a labeled analogue of an ACE inhibitor, demonstrates its direct contribution to drug development. Beyond pharmaceuticals, it finds use in creating biomaterials and in studies investigating collagen-related diseases and their treatments.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-purity Boc-L-Hydroxyproline (CAS: 13726-69-7) to the scientific community. We understand that the success of peptide synthesis and related research hinges on the quality of the intermediates used. Our commitment to excellence ensures that researchers have access to a reliable and consistent source of this vital compound, thereby facilitating their work in drug discovery, biochemical research, and beyond.

In essence, Boc-L-Hydroxyproline is more than just an amino acid derivative; it is a key enabler in peptide chemistry. Its protected nature and functional hydroxyl group make it invaluable for synthesizing peptides with specific structures and functions. By partnering with NINGBO INNO PHARMCHEM CO.,LTD., researchers can confidently procure this essential intermediate, driving progress in their peptide chemistry endeavors.