The landscape of cancer treatment is continuously evolving, with Antibody-Drug Conjugates (ADCs) emerging as a highly promising therapeutic modality. ADCs combine the specificity of monoclonal antibodies with the potent cytotoxicity of small-molecule drugs, offering a targeted approach to combatting cancer. At the heart of a successful ADC lies a robust linker, and one such critical component is Suberate Bis(sulfosuccinimidyl) Sodium Salt, commonly known as BS3 Crosslinker. As a leading manufacturer and supplier of specialized chemical intermediates in China, we understand the vital role BS3 plays in bioconjugation and ADC development.

Understanding BS3 Crosslinker: A Non-Cleavable Linker

BS3 Crosslinker, with the CAS number 127634-19-9, is a homobifunctional crosslinker. This means it possesses two identical reactive groups that can react with specific functional groups on biomolecules, typically primary amines. Its defining characteristic is being a non-cleavable linker, which is crucial for the stability of the ADC. Unlike cleavable linkers that can be degraded in the bloodstream, non-cleavable linkers ensure that the cytotoxic payload remains securely attached to the antibody until it reaches the target cancer cell. This stability minimizes premature drug release, thereby reducing systemic toxicity and improving the therapeutic index of the ADC.

Applications in Bioconjugation and ADC Synthesis

The primary application for BS3 Crosslinker is in the synthesis of Antibody-Drug Conjugates. Researchers and pharmaceutical companies seek reliable suppliers for high-purity BS3 to conjugate cytotoxic payloads to antibodies. The process involves reacting the primary amine groups on the antibody (e.g., lysine residues) with the NHS ester groups of BS3, followed by conjugation of the drug to the other end of the linker. This precise chemical reaction is fundamental to creating effective ADCs. For those looking to buy BS3 Crosslinker for their ADC projects, sourcing from reputable manufacturers like us in China guarantees the quality and consistency required for successful drug development.

Why Choose a Chinese Manufacturer for BS3 Crosslinker?

As a dedicated supplier of pharmaceutical intermediates, our manufacturing facilities in China are equipped to produce Suberate Bis(sulfosuccinimidyl) Sodium Salt with high purity, typically exceeding 90% as confirmed by HNMR. We understand the stringent requirements of the biopharmaceutical industry. By choosing us, you benefit from:

  • Competitive Pricing: Access high-quality BS3 Crosslinker at competitive prices, making your research and development budgets more manageable.
  • Reliable Supply: Our robust manufacturing infrastructure ensures a consistent and dependable supply chain, crucial for uninterrupted research and production.
  • Guaranteed Quality: We adhere to strict quality control measures, ensuring that every batch of BS3 Crosslinker meets the highest purity standards.
  • Expert Support: Leverage our expertise in chemical synthesis and supply chain management.

For researchers and procurement managers aiming to purchase Suberate Bis(sulfosuccinimidyl) Sodium Salt, it is imperative to partner with a manufacturer that prioritizes quality and reliability. Our commitment is to empower your scientific endeavors by providing the essential building blocks for next-generation therapeutics.

If you are looking to buy BS3 Crosslinker or any other critical bioconjugation reagents, we are your trusted partner. Contact us today to inquire about pricing, availability, and to secure a reliable supply of this essential ADC linker from China.