The development of advanced biologics, particularly Antibody-Drug Conjugates (ADCs), hinges on the precise control of chemical reactions and the quality of reagents used. Suberate Bis(sulfosuccinimidyl) Sodium Salt, also known as BS3 Crosslinker, with CAS number 127634-19-9, is a cornerstone reagent in this field. As a prominent manufacturer and supplier from China, we provide this critical chemical intermediate, recognized for its role as a non-cleavable crosslinker, enabling the creation of stable and effective bioconjugates.

The Molecular Backbone: Understanding BS3 Crosslinker's Structure and Reactivity

Suberate Bis(sulfosuccinimidyl) Sodium Salt is characterized by its suberate (an eight-carbon dicarboxylic acid) backbone, with each carboxyl group esterified to N-hydroxysuccinimide (NHS) and further modified with a sulfonate group. This structure results in two reactive NHS ester moieties, which are highly susceptible to nucleophilic attack by primary amines. These amine groups are abundant in biological molecules, particularly the epsilon-amino groups of lysine residues found in proteins and antibodies. The reaction between the NHS ester and the amine forms a stable amide bond, effectively crosslinking the two molecules. The presence of the sulfonate groups enhances the aqueous solubility of the compound, making it easier to handle in biological buffers. For researchers and developers aiming to buy BS3 Crosslinker, understanding this chemical reactivity is key to optimizing conjugation strategies.

The Critical Function: Non-Cleavable Linkers in ADCs

In the context of Antibody-Drug Conjugates, the linker's stability is paramount. BS3 Crosslinker's non-cleavable nature ensures that the drug payload remains firmly attached to the antibody throughout circulation in the body. This is vital for preventing premature drug release, which could lead to off-target toxicity and reduced therapeutic efficacy. The drug is only released once the ADC has been internalized by the target cell, often through lysosomal degradation pathways that can cleave the antibody, but not the linker itself. This controlled release mechanism is what makes BS3 Crosslinker an indispensable tool for creating potent and safe ADCs. Procuring high-quality BS3 Crosslinker from reliable suppliers like us is therefore essential for robust ADC development.

Sourcing BS3 Crosslinker: Our Commitment as a China Manufacturer

Our company is dedicated to supporting the biopharmaceutical industry by manufacturing and supplying Suberate Bis(sulfosuccinimidyl) Sodium Salt with exceptional purity (HNMR > 90%). Based in China, we offer:

  • Consistent Quality: We ensure that our BS3 Crosslinker meets stringent specifications for purity and reactivity, crucial for reproducible results.
  • Scalable Production: Whether you require small quantities for research or larger batches for clinical trials, our manufacturing capabilities can meet your demands.
  • Competitive Pricing: We provide cost-effective solutions, allowing more researchers to access high-quality reagents for their critical projects.
  • Reliable Distribution: We manage a streamlined supply chain to ensure timely delivery of your orders worldwide.

For scientists and procurement specialists looking to purchase Suberate Bis(sulfosuccinimidyl) Sodium Salt, we are your premier choice. We understand the technical demands of bioconjugation and are committed to providing the materials that drive innovation in drug discovery and development. Reach out to us to inquire about pricing and to place your order for this essential biopharmaceutical intermediate.