In the realm of biochemical research and pharmaceutical development, precision and specificity are not just desirable traits; they are fundamental requirements for achieving meaningful results and developing effective therapies. Kinases, enzymes that regulate a vast array of cellular functions through phosphorylation, are frequently implicated in diseases when their activity is dysregulated. 1-NM-PP1 (CAS 221244-14-0) is a prime example of a chemical tool designed to offer this crucial specificity, particularly in targeting mutant forms of kinases. As a dedicated manufacturer and supplier of high-quality research chemicals, we are committed to empowering scientific advancement with compounds like 1-NM-PP1.

1-NM-PP1 distinguishes itself as a cell-permeable analog of PP1, engineered to act as a potent and selective inhibitor of kinases that have been modified through specific mutations. This targeted inhibition is achieved via an ATP-competitive mechanism, meaning it competes with ATP for binding to the kinase’s active site. The key advantage lies in its vastly superior affinity for mutated kinases compared to their wild-type counterparts, with IC50 values often showing a difference of several orders of magnitude. For instance, a mutant kinase might be inhibited with an IC50 in the nanomolar range, while the wild-type enzyme requires micromolar concentrations for similar inhibition. This characteristic makes 1-NM-PP1 an indispensable tool for researchers aiming to dissect the specific roles of mutated kinases in cellular signaling and disease progression.

The applications of 1-NM-PP1 are diverse and impactful. In oncology, where specific kinase mutations often drive tumor growth and metastasis, 1-NM-PP1 can be used to study these oncogenic pathways and screen for potential drug candidates. It's also vital in fundamental research for understanding the nuances of kinase biology and identifying downstream signaling events. For researchers seeking to purchase 1-NM-PP1, partnering with a reliable manufacturer like NINGBO INNO PHARMCHEM ensures access to a product that meets rigorous purity standards, typically exceeding 95%. This high purity is critical for the accuracy and reproducibility of experimental outcomes. We are a leading supplier dedicated to providing this quality.

Procuring specialized research chemicals requires a supplier that understands the critical nature of their function. When you buy 1-NM-PP1 from NINGBO INNO PHARMCHEM, you benefit from our expertise as a manufacturer committed to consistent quality and reliable supply. We provide comprehensive documentation, including detailed specifications and Certificates of Analysis, so you can be confident in the integrity of the compound. Our aim is to facilitate your research by removing any concerns about the quality or availability of essential reagents. We are a manufacturer ready to serve your needs.

In essence, 1-NM-PP1 exemplifies the power of chemical specificity in scientific research. Its ability to precisely target mutant kinases provides invaluable insights into cellular mechanisms and opens avenues for novel therapeutic interventions. We invite all researchers and procurement specialists to consider NINGBO INNO PHARMCHEM for their 1-NM-PP1 requirements. Contact us today to request a quote and sample, and experience the assurance of quality and expertise from a leading chemical supplier.