In the realm of diagnostic imaging, Magnetic Resonance Imaging (MRI) stands as a powerful tool, offering unparalleled detail of soft tissues. However, to further enhance clarity and diagnostic precision, contrast agents are often employed. Among the advanced options available, Gadobutrol (CAS: 138071-82-6) has emerged as a significant player. As a leading manufacturer and supplier of high-quality pharmaceutical intermediates in China, NINGBO INNO PHARMCHEM CO.,LTD. is proud to offer this sophisticated MRI contrast agent.

Gadobutrol is a macrocyclic, extracellular, non-ionic gadolinium-based contrast agent (GBCA). Its key distinguishing feature is its high concentration, typically formulated at 1.0 mmol/mL. This concentration is often double that of other standard GBCAs. This unique formulation translates directly into tangible benefits for imaging professionals. Firstly, it allows for a reduced injection volume while delivering a comparable or even superior diagnostic effect. Secondly, the higher concentration facilitates a more compact bolus of contrast material during administration, which is particularly advantageous for dynamic imaging sequences, such as those used in Magnetic Resonance Angiography (MRA) and perfusion imaging. A tighter bolus means sharper contrast enhancement and improved temporal resolution, allowing for more accurate assessment of blood flow and tissue perfusion.

The efficacy of Gadobutrol extends across a broad spectrum of MRI applications. In Central Nervous System (CNS) imaging, it is instrumental in identifying disruptions in the blood-brain barrier and abnormal vascularity, crucial for diagnosing conditions like tumors, inflammation, and vascular malformations. For MRA, Gadobutrol aids in visualizing arteries throughout the body, including the supra-aortic and renal arteries, assisting in the detection of stenosis, aneurysms, and other vascular abnormalities. Its utility also extends to cardiac MRI (CMRI), where it helps assess myocardial perfusion and late gadolinium enhancement, providing vital information for the diagnosis and management of coronary artery disease.

From a chemical perspective, Gadobutrol's macrocyclic structure contributes to its high kinetic and thermodynamic stability. This stability is important for minimizing the release of free gadolinium ions in vivo, a factor that has been a subject of discussion regarding the long-term safety of GBCAs. As a reputable supplier, we ensure that our Gadobutrol meets stringent quality standards, providing peace of mind to our clients. For those seeking to buy Gadobutrol, understanding its performance characteristics is key. The improved relaxivity of Gadobutrol enhances signal intensity on T1-weighted images, leading to clearer differentiation between normal and pathological tissues.

When considering the procurement of pharmaceutical intermediates like Gadobutrol, factors such as quality, consistency, and price are paramount. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a dependable partner for research institutions and pharmaceutical companies. We understand the critical role our products play in medical diagnostics and are dedicated to providing exceptional service and competitive pricing for bulk orders. If you are looking to source high-quality Gadobutrol, a trusted manufacturer from China, we encourage you to contact us for a quote and sample to experience the difference our commitment to excellence makes.