The development of effective anticoagulants has revolutionized the treatment of thrombotic disorders. Among these, Rivaroxaban stands out as a widely prescribed direct oral anticoagulant (DOAC). The journey from raw chemical to a finished pharmaceutical product is complex, relying heavily on the availability of high-quality intermediates. One such critical component is (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride, identified by CAS number 898543-06-1. Understanding its role and the importance of sourcing it from reputable manufacturers is paramount for the pharmaceutical industry.

The Chemical Backbone of Rivaroxaban:

Rivaroxaban, marketed under brand names like Xarelto, is a selective inhibitor of Factor Xa, a crucial enzyme in the blood coagulation cascade. Its efficacy and safety profile are directly linked to the purity and precise chemical structure of its precursor materials. (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride (CAS 898543-06-1) serves as a vital intermediate in the intricate multi-step synthesis of Rivaroxaban. The presence of the specific stereochemistry (S configuration) and functional groups within this intermediate is essential for the correct three-dimensional structure of the final active pharmaceutical ingredient (API).

Why Sourcing from a Dedicated Manufacturer Matters:

The pharmaceutical industry demands the highest standards of purity, consistency, and traceability for all its raw materials. When it comes to intermediates like CAS 898543-06-1, purchasing from a specialized manufacturer, particularly one based in China known for its fine chemical production capabilities, offers several advantages. A dedicated manufacturer can guarantee:

  • High Purity Levels: Pharmaceutical synthesis requires intermediates with minimal impurities to prevent side reactions and ensure the safety and efficacy of the final drug. Manufacturers capable of achieving ≥99% purity for (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride are invaluable.
  • Consistent Supply: The continuous production of life-saving medications like Rivaroxaban depends on an uninterrupted supply of key intermediates. Reliable manufacturers maintain robust production capacities and supply chains to meet global demand.
  • Competitive Pricing: Sourcing directly from a manufacturer in China often translates to more competitive pricing, allowing pharmaceutical companies to manage their production costs effectively. Inquiring about the price for this Rivaroxaban intermediate directly from a supplier can yield significant savings.
  • Technical Support and Documentation: Reputable suppliers provide comprehensive technical data, certificates of analysis (CoA), and support, which are critical for regulatory compliance and quality assurance in pharmaceutical manufacturing.

Navigating the Market: Finding the Right Supplier

For procurement managers and R&D scientists, identifying the right supplier for (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride involves looking beyond just the CAS number. Key considerations include the supplier's manufacturing capabilities, adherence to quality management systems (like ISO), and their experience in serving the global pharmaceutical market. When searching to buy this crucial pharmaceutical intermediate, focus on manufacturers who can provide transparent pricing and reliable delivery terms.

In conclusion, the availability of high-quality (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride (CAS 898543-06-1) from trusted manufacturers is a cornerstone of modern anticoagulant therapy. By understanding the importance of this intermediate and partnering with reliable suppliers, the pharmaceutical industry can continue to provide essential medications like Rivaroxaban to patients worldwide.