For procurement professionals and R&D scientists in the pharmaceutical industry, the meticulous selection of chemical intermediates is foundational to successful drug development and manufacturing. When sourcing a critical component like (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride, CAS 898543-06-1, understanding its precise chemical specifications is paramount. This guide aims to illuminate these specifications and empower buyers to make informed decisions when dealing with suppliers, especially those in China.

The Foundation: CAS Number and Chemical Identity

The Chemical Abstracts Service (CAS) registry number, 898543-06-1, uniquely identifies this specific compound. It signifies (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride. Accurate identification ensures that buyers are procuring the exact molecule required for Rivaroxaban synthesis. Synonyms, such as 'Rivaroxaban intermediate' or specific chemical nomenclature variations, are also important to cross-reference for complete clarity.

Key Specifications to Scrutinize:

When requesting quotes or assessing supplier capabilities for CAS 898543-06-1, buyers should pay close attention to the following critical specifications:

  1. Purity: This is arguably the most critical parameter. Pharmaceutical intermediates typically require very high purity levels, often ≥98% or ≥99% as determined by analytical techniques like High-Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC). A supplier's Certificate of Analysis (CoA) should clearly state the purity and the method used for its determination.
  2. Molecular Formula and Weight: The molecular formula (C14H17N3O4.HCl) and molecular weight (approximately 327.77 g/mol) are fundamental identifiers that should align with the requested compound.
  3. Appearance: The physical appearance, typically described as a 'White powder' for this hydrochloride salt, provides a quick visual check for consistency. Significant deviations in color or form might indicate issues.
  4. Stereochemical Purity (Enantiomeric Purity): Given the importance of stereochemistry in Rivaroxaban synthesis, the enantiomeric purity of the (S)-isomer is crucial. Specifications might be listed as '>95% ee' or '>98% ee'. This is often determined by chiral chromatography. Buyers should always confirm this specification.
  5. Moisture Content: High moisture content can affect stability, reactivity, and accurate weighing. Suppliers may specify a maximum allowable moisture level.
  6. Residual Solvents: Depending on the synthesis process, residual solvents might be present. Pharmaceutical intermediates often have strict limits on certain residual solvents, which should be detailed in the CoA.
  7. Storage Conditions: Understanding the recommended storage temperature (e.g., room temperature, under dry conditions) is important for maintaining the intermediate's quality during transit and upon receipt.

The Role of the Certificate of Analysis (CoA):

The CoA is the primary document from a supplier that validates the quality of the chemical. It should detail the specific batch's test results against agreed-upon specifications. Buyers should always request and review the CoA before accepting a shipment. When buying from manufacturers in China, ensure they provide comprehensive and accurate CoAs that meet international pharmaceutical standards.

Conclusion: Informed Procurement for Quality Outcomes

By diligently examining these chemical specifications and working with transparent suppliers who provide robust documentation, pharmaceutical professionals can ensure they are sourcing high-quality (S)-4-(4-(5-(aminomethyl)-2-oxo-3-oxazolidinyl)phenyl)morpholin-3-one hydrochloride (CAS 898543-06-1). This attention to detail in procurement is vital for the successful, cost-effective, and compliant synthesis of Rivaroxaban, ultimately benefiting patient health.