In the realm of biochemical research and pharmaceutical development, understanding the precise function and application of key reagents is crucial. Suberate Bis(sulfosuccinimidyl) Sodium Salt, widely recognized as BS3 Crosslinker (CAS: 127634-19-9), stands out as a versatile and indispensable tool, particularly in the field of bioconjugation. As a specialized manufacturer and supplier based in China, we offer this high-purity white solid powder and are dedicated to explaining its scientific underpinnings and broad utility.

Deconstructing the Chemistry of BS3 Crosslinker

BS3 Crosslinker is a homobifunctional crosslinking agent. Its molecular structure features two N-hydroxysuccinimide (NHS) ester groups at either end of an eight-carbon suberate chain, further enhanced by sulfonate groups for improved water solubility. The NHS ester groups are highly reactive towards primary amines, forming stable amide linkages. This bifunctional nature allows BS3 to bridge two molecules that possess primary amine functionalities. In essence, it acts as a chemical 'glue' to covalently link biomolecules. The non-cleavable characteristic of the suberate linker is a critical design feature, ensuring that once molecules are crosslinked, they remain joined under physiological conditions, which is vital for applications like Antibody-Drug Conjugates (ADCs).

Key Applications and Their Significance

The primary and most impactful application of BS3 Crosslinker is in the synthesis of Antibody-Drug Conjugates (ADCs). ADCs represent a significant advancement in cancer therapy, delivering cytotoxic agents directly to tumor cells via a targeting antibody. The stability imparted by non-cleavable linkers like BS3 is essential for the safe and effective operation of ADCs. Beyond ADCs, BS3 is utilized in various biochemical assays and research contexts, including:

  • Protein Stabilization: Crosslinking can help stabilize protein structures, preventing denaturation or aggregation.
  • Protein-Protein Interaction Studies: BS3 can be used to covalently capture interacting protein complexes for analysis.
  • Immunological Assays: It can be used to conjugate antibodies or antigens to solid supports or detection molecules.

For scientists looking to buy BS3 Crosslinker, understanding these applications highlights its importance in advancing research and developing new therapeutics.

Why Choose Our BS3 Crosslinker?

Our commitment as a China-based manufacturer extends to providing BS3 Crosslinker that meets the highest standards. We ensure:

  • Exceptional Purity: Our rigorous quality control processes guarantee a minimum HNMR purity of >90%, crucial for sensitive biological reactions.
  • Reliable Manufacturing: We operate advanced facilities, ensuring consistent product quality and scalable production capabilities.
  • Competitive Pricing: We offer cost-effective solutions without compromising on the quality of our chemical intermediates.
  • Global Supply: We are equipped to supply BS3 Crosslinker to researchers and companies worldwide, ensuring timely delivery.

If you are in need of high-quality Suberate Bis(sulfosuccinimidyl) Sodium Salt for your research or development projects, we are your trusted supplier. Contact us today to learn more about our product specifications, inquire about pricing, and place your order.