The pharmaceutical industry relies on a vast array of specialized chemical intermediates to synthesize life-saving medications. Among these, Tolvaptan Intermediate, identified by CAS number 137977-97-0, plays a pivotal role in the production of Tolvaptan. Understanding its applications is crucial for researchers and manufacturers aiming for efficient and successful drug development. This article highlights the key uses of this intermediate in pharmaceutical synthesis.

The Core Role in Tolvaptan Synthesis

The primary and most significant application of 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one (CAS 137977-97-0) is as a key intermediate in the multi-step synthesis of Tolvaptan. Tolvaptan is a selective vasopressin V2-receptor antagonist used clinically to treat patients with hyponatremia (low sodium levels in the blood), often associated with conditions like heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Significance in API Manufacturing

The journey from basic chemical precursors to a finished pharmaceutical product involves numerous transformations. Intermediates like CAS 137977-97-0 are vital stages in this process. Their precise chemical structure and high purity are essential for ensuring that the subsequent synthetic steps yield the desired Active Pharmaceutical Ingredient (API) with the correct stereochemistry and minimal by-products. By sourcing high-quality Tolvaptan Intermediate, manufacturers can:

  • Ensure the structural integrity of the final Tolvaptan API.
  • Maintain high yields in synthesis reactions.
  • Minimize purification challenges and associated costs.
  • Meet regulatory requirements for API purity and safety.

At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to supplying pharmaceutical manufacturers with intermediates that meet rigorous quality standards. Our Tolvaptan Intermediate (CAS 137977-97-0) is produced with meticulous attention to detail, ensuring it serves as a reliable foundation for your API synthesis needs. We understand the importance of this compound in the healthcare sector and strive to be a dependable source for purchase.

Applications in Research and Development

Beyond large-scale API production, this intermediate also finds application in pharmaceutical research and development (R&D). Scientists may use it for:

  • Exploring alternative synthetic pathways to Tolvaptan.
  • Developing novel analogs or derivatives of Tolvaptan with potentially improved therapeutic profiles.
  • Conducting process chemistry studies to optimize existing manufacturing routes.
  • Utilizing it as a reference standard in analytical method development for quality control of Tolvaptan production.

We cater to R&D needs as well, offering flexible quantities for purchase to support groundbreaking research. Engaging with our sales team for an inquiry will provide you with the necessary information to procure this intermediate for your specific R&D projects.

Conclusion

The utility of Tolvaptan Intermediate (CAS 137977-97-0) is primarily centered on its indispensable role in the synthesis of the pharmaceutical drug Tolvaptan. Its availability in high purity from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for both established API production and innovative R&D efforts. We invite you to contact us to learn more about our offerings and to arrange for the purchase of this critical pharmaceutical intermediate.