The modern chemical landscape is rich with versatile building blocks that facilitate complex synthesis and innovation. Among these, Trans-N-Boc-1,4-Cyclohexanediamine (CAS 177906-48-8) stands out as a particularly useful intermediate, widely employed in research and development across various chemical disciplines.

This compound, with its chemical formula C11H22N2O2 and a molecular weight of 214.30, is a white solid. Its structure features a cyclohexane ring with two amine functionalities positioned at the 1 and 4 positions in a trans stereochemical arrangement. One of these amine groups is protected by a tert-butyloxycarbonyl (Boc) group. This Boc protection serves a critical role in synthetic organic chemistry by temporarily masking the amine's reactivity, allowing for selective chemical transformations at other parts of the molecule or at the unprotected amine. The ease with which the Boc group can be removed under acidic conditions makes it an ideal protecting group for multi-step syntheses.

The utility of Trans-N-Boc-1,4-Cyclohexanediamine extends across several research frontiers. In pharmaceutical synthesis, it acts as a foundational component for creating sophisticated drug candidates. Its rigid cyclic structure and the presence of two amine groups (one protected, one free) make it an excellent starting point for developing molecules with specific three-dimensional shapes, which is crucial for drug-target interactions. Researchers often buy this compound to incorporate into peptide mimetics, receptor antagonists, or as a linker in antibody-drug conjugates (ADCs).

In academic and industrial organic synthesis labs, Trans-N-Boc-1,4-Cyclohexanediamine is valued for its role as a chiral building block. Its inherent trans stereochemistry allows chemists to introduce specific spatial arrangements into target molecules, which is essential for creating enantiomerically pure compounds. This compound can be utilized in the design of ligands for metal catalysts, improving catalytic efficiency and selectivity in various organic reactions. For researchers needing to purchase this material, looking for suppliers who provide a high degree of purity (e.g., 97%+) and reliable batch consistency is key.

Procuring chemical intermediates like Trans-N-Boc-1,4-Cyclohexanediamine involves careful selection of suppliers. Manufacturers based in China often offer competitive pricing, especially for bulk quantities, making it an attractive option for R&D departments and larger chemical companies. When sourcing, it is important to work with suppliers who can provide comprehensive documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (COA), confirming the product's specifications and handling requirements.

In summary, Trans-N-Boc-1,4-Cyclohexanediamine is a highly versatile intermediate with significant applications in pharmaceutical synthesis and general organic chemistry. Its unique structural features and the presence of the Boc protecting group make it an invaluable tool for researchers. By partnering with reliable global suppliers, particularly manufacturers in China, R&D professionals can ensure access to this critical building block, driving forward innovation in chemical sciences.