The incorporation of fluorine atoms, particularly trifluoromethyl groups (-CF3), into organic molecules is a cornerstone of modern medicinal and materials chemistry. These groups can dramatically alter a molecule's properties, including lipophilicity, metabolic stability, and binding affinity. Among the reagents enabling these transformations, 1,1-Dibromo-3,3,3-trifluoroacetone (CAS 431-67-4) plays a notable role.

Introducing the Trifluoromethyl Group

1,1-Dibromo-3,3,3-trifluoroacetone serves as a convenient and reactive source for introducing the trifluoromethyl moiety into various molecular frameworks. Its unique structure allows for controlled reactions, facilitating the synthesis of complex organic compounds that are otherwise challenging to prepare. This makes it an invaluable reagent for chemists aiming to develop novel pharmaceuticals, agrochemicals, and advanced materials.

Key Synthetic Pathways Enhanced by this Intermediate

Beyond direct trifluoromethylation, this dibromo-trifluoroacetone derivative is instrumental in several important synthetic pathways:

  • Synthesis of Pyrazoles: It is a key precursor for creating 3,4-disubstituted pyrazole analogues, which are vital in the search for new anti-cancer agents, specifically targeting CDK inhibitors.
  • Heterocyclic Chemistry: Its reactivity makes it suitable for constructing various trifluoromethyl-containing heterocyclic systems, which are prevalent in many bioactive molecules.
  • Intermediate Preparation: It can be converted into trifluoropyruvaldehyde hydrate, a versatile intermediate for synthesizing fused pyrazine derivatives and other nitrogen-containing heterocycles.
  • Agrochemical Development: The compound finds application in preparing intermediates for herbicides and other crop protection agents.

Procuring Reliable Reagents

For chemists and procurement specialists looking to acquire 1,1-Dibromo-3,3,3-trifluoroacetone, understanding supplier credentials is vital. When you need to buy this chemical, prioritizing suppliers who guarantee high purity (e.g., 98%) and offer consistent quality is paramount for reproducible research results. We understand the importance of reliable chemical sourcing and are a dedicated supplier of high-quality intermediates. If you are searching for 'CAS 431-67-4 price' or a dependable chemical manufacturer, our offerings are designed to meet your stringent requirements.

Considerations for Purchase

When procuring 1,1-Dibromo-3,3,3-trifluoroacetone, consider the following:

  • Purity and Testing: Always request a Certificate of Analysis (COA) to verify the purity and confirm lot-specific data.
  • Supplier Reputation: Choose manufacturers with a proven track record in chemical production and a commitment to quality control.
  • Scalability: Ensure the supplier can meet your needs from small research quantities to larger bulk orders.

We are proud to support the scientific community with essential chemical building blocks. For your trifluoromethylation and heterocyclic synthesis needs, consider us your go-to supplier for 1,1-Dibromo-3,3,3-trifluoroacetone. Contact us today to discuss your requirements and get a quote.