For professionals in the chemical industry, understanding the nuances of key compounds is fundamental. This article provides a concise overview of 1,1-Dibromo-3,3,3-trifluoroacetone (CAS 431-67-4), detailing its properties, common synonyms, and crucial applications in various synthetic processes.

Understanding 1,1-Dibromo-3,3,3-trifluoroacetone

Chemical Identity:
CAS Number: 431-67-4
Synonyms: 3,3-Dibromo-1,1,1-trifluoroacetone, 1,1,1-Trifluoro-3,3-dibromoacetone, 3,3-Dibromo-1,1,1-trifluoropropan-2-one, Dibromotrifluoroacetone.
Molecular Formula: C3HBr2F3O
Molecular Weight: 269.84 g/mol
Appearance: Typically a light-orange or pale yellow liquid.

Physicochemical Properties Relevant to Synthesis

This compound exhibits a boiling point in the range of 111-113 °C and a density of approximately 1.98. Its solubility in organic solvents like chloroform is good, but it shows limited miscibility with water. These properties are important considerations for reaction setup, work-up procedures, and purification processes. For optimal stability, it is often stored under an inert atmosphere at refrigerated temperatures (2-8 °C).

Key Applications in Chemical Synthesis

The primary utility of 1,1-Dibromo-3,3,3-trifluoroacetone lies in its role as a versatile intermediate in organic synthesis, particularly in the following areas:

  • Pharmaceutical Intermediates: It is a critical precursor for synthesizing analogues of pyrazoles, which are investigated for their potential as anti-tumor CDK inhibitors. This application is vital for companies focused on oncology drug development.
  • Trifluoromethyl Chemistry: The compound is an effective reagent for introducing trifluoromethyl groups into organic molecules, a modification that often enhances biological activity and metabolic stability.
  • Heterocyclic Synthesis: It participates in reactions that form complex heterocyclic structures, essential for a wide range of pharmaceutical and agrochemical applications.
  • Precursor for Hydrates: It can be readily converted to trifluoropyruvaldehyde hydrate, a useful intermediate in the synthesis of fused pyrazine derivatives.

Sourcing and Quality Assurance

For chemists and procurement professionals looking to buy 1,1-Dibromo-3,3,3-trifluoroacetone, ensuring quality and reliability from suppliers is paramount. When searching for this chemical, consider manufacturers that provide detailed product specifications and Certificates of Analysis (COA) to confirm purity, often exceeding 98%. Partnering with established chemical suppliers, especially those with a strong presence in China's manufacturing sector, can provide access to competitive pricing and a stable supply chain. We are a trusted supplier dedicated to providing high-grade chemical intermediates to support your research and development needs.

We encourage you to contact us for inquiries regarding pricing, bulk orders, and specific technical data for 1,1-Dibromo-3,3,3-trifluoroacetone. Our team is ready to assist you in acquiring this essential chemical building block.