In the realm of fine chemicals and pharmaceutical intermediates, a deep understanding of product properties is crucial for effective application and procurement. 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine, known by its CAS number 74853-08-0, is a prime example of such a compound. Its specific chemical characteristics and established applications make it a sought-after material for researchers and manufacturers in the pharmaceutical sector.

Chemically, 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine possesses the molecular formula C16H19N3O and a molecular weight of approximately 269.34 g/mol. It is typically supplied as a light brown to brown solid, with a reported melting point often in the range of 234-240°C. These physical properties are important for handling, storage, and formulation. Its solubility profile, often noting slight solubility in DMSO and very slight solubility in methanol even when heated, guides its use in various reaction media. The presence of amine and hydroxyl functional groups makes it a versatile building block in organic synthesis.

The primary and most significant application of 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine is its role as a key intermediate in the synthesis of Posaconazole. Posaconazole is a highly effective antifungal drug, essential for treating invasive fungal infections, particularly in patients with weakened immune systems. The pharmaceutical industry relies on a consistent supply of high-purity 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine from reputable manufacturers to ensure the quality and efficacy of the final Posaconazole API. Companies looking to buy this intermediate can expect suppliers to offer it with assays typically above 97%.

Beyond its application in Posaconazole synthesis, this piperazine derivative can also serve as a valuable intermediate in other areas of medicinal chemistry and drug discovery. Its bifunctional nature allows for various chemical modifications, making it adaptable for creating novel compounds with potential therapeutic properties. Researchers often seek out this compound for its utility in developing new APIs or exploring different synthetic routes.

For procurement professionals, understanding these properties and applications is vital when sourcing 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine. Engaging with suppliers who can provide detailed specifications, safety data sheets (SDS), and certificates of analysis is crucial for ensuring that the procured material meets the stringent requirements of pharmaceutical manufacturing. Whether for research and development or commercial-scale production, securing a reliable source of this intermediate is paramount for success.