For procurement managers and R&D scientists in the pharmaceutical and fine chemical industries, identifying reliable sources for critical intermediates is paramount. (1S,2S,3R,5S)-(+)-2,3-Pinanediol, identified by CAS number 18680-27-8, stands out as a high-value chiral building block. Understanding its properties, applications, and how to effectively source it from reputable manufacturers is key to project success.

What is (1S,2S,3R,5S)-(+)-2,3-Pinanediol?

(1S,2S,3R,5S)-(+)-2,3-Pinanediol is a bicyclic monoterpene diol. Its specific stereochemistry makes it particularly valuable in chiral synthesis. Typically appearing as a white to light beige crystalline powder, it offers high purity, often exceeding 99.0%, which is essential for its demanding applications. Its melting point typically ranges from 53-57°C, and it exhibits good solubility in common organic solvents like toluene, chloroform, and methanol.

Key Applications in Pharmaceutical Synthesis

The primary driver for demand for (1S,2S,3R,5S)-(+)-2,3-Pinanediol is its role as a critical intermediate in the synthesis of Bortezomib. Bortezomib is a proteasome inhibitor used in the treatment of multiple myeloma and mantle cell lymphoma. The precise stereochemical configuration of (1S,2S,3R,5S)-(+)-2,3-Pinanediol is crucial for achieving the desired therapeutic efficacy of the final drug product. For those looking to buy this intermediate for Bortezomib production, ensuring consistent high purity and a reliable supply chain is non-negotiable. Procurement managers often search for '(1S,2S,3R,5S)-(+)-2,3-Pinanediol manufacturer China' to secure these vital materials.

Beyond Bortezomib, this compound serves as a versatile chiral reagent or chiral building block in other asymmetric synthesis routes. Its unique bicyclic structure can be leveraged to introduce specific stereocenters into target molecules, which is fundamental in the development of new pharmaceuticals and agrochemicals where enantiomeric purity dictates biological activity and safety.

Sourcing Strategies for Procurement Managers

When looking to purchase (1S,2S,3R,5S)-(+)-2,3-Pinanediol, procurement professionals should consider several factors. First, verifying the purity (e.g., ≥99.0%) and understanding the analytical data (like NMR, IR, and optical rotation) is critical. Second, establishing relationships with reputable manufacturers and suppliers, particularly those with ISO certifications and a proven track record, is essential for quality assurance and consistent delivery. Searching for 'buy (1S,2S,3R,5S)-(+)-2,3-Pinanediol online' or 'CAS 18680-27-8 price' will yield numerous options, but due diligence is key.

Partnering with established suppliers in China offers a competitive advantage due to the concentration of chemical manufacturing expertise in the region. Companies specializing in pharmaceutical intermediates often provide detailed product specifications, Certificates of Analysis (CoA), and robust customer support, making the procurement process smoother. For any inquiry about pricing or bulk orders, reaching out to these specialized suppliers directly is the most effective approach.

In conclusion, (1S,2S,3R,5S)-(+)-2,3-Pinanediol is an indispensable chemical for advanced synthesis. By understanding its importance and employing smart sourcing strategies, R&D scientists and procurement managers can secure the high-quality materials needed to drive innovation in pharmaceutical development.