The pharmaceutical industry constantly seeks efficient and pure intermediates to synthesize life-saving drugs. Among these essential compounds, (1S,2S,3R,5S)-(+)-2,3-Pinanediol, identified by CAS 18680-27-8, plays a significant role. This bicyclic diol, typically supplied as a white powder with a purity of ≥99.0%, is a cornerstone for several advanced synthetic pathways, most notably in the production of Bortezomib. For R&D scientists and procurement specialists, understanding its value and sourcing channels is crucial.

The Significance of (1S,2S,3R,5S)-(+)-2,3-Pinanediol in Drug Synthesis

As a pharmaceutical intermediate, (1S,2S,3R,5S)-(+)-2,3-Pinanediol offers unique structural features that facilitate complex molecular construction. Its primary acclaimed use is in the synthesis of Bortezomib, a proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The precise stereochemistry of this pinanediol derivative is paramount in ensuring the efficacy and safety of the final Bortezomib product. This demand drives many pharmaceutical companies to actively search for reliable manufacturers and suppliers who can provide 'high purity (1S,2S,3R,5S)-(+)-2,3-Pinanediol'.

Furthermore, the compound's inherent chirality makes it a valuable building block in a broader range of pharmaceutical applications. It can be used in the synthesis of other chiral drugs, agrochemicals, and fine chemicals where controlling stereochemistry is critical for biological activity. Researchers often employ it as a chiral auxiliary or a synthon for introducing specific stereocenters into larger molecules.

Procurement Considerations for Pharmaceutical Intermediates

For procurement managers tasked with sourcing pharmaceutical intermediates like (1S,2S,3R,5S)-(+)-2,3-Pinanediol, several key factors must be prioritized. Firstly, quality and purity are non-negotiable. Specifications such as '≥99.0% purity' and detailed analytical data are essential. Secondly, supply chain reliability is paramount, especially for intermediates used in GMP (Good Manufacturing Practice) environments. Companies should seek suppliers with established quality management systems and a history of consistent delivery. When searching for 'CAS 18680-27-8 price', it's important to balance cost with quality and supplier reputation.

Many global pharmaceutical companies source such intermediates from specialized chemical manufacturers in regions like China, which offers competitive pricing and a robust manufacturing infrastructure. It is advisable to look for suppliers who can provide comprehensive documentation, including batch-specific Certificates of Analysis (CoA), to ensure compliance with regulatory requirements and internal quality standards. Engaging with suppliers early for 'bulk quotes' can secure better pricing and ensure future availability for ongoing production needs.

In summary, (1S,2S,3R,5S)-(+)-2,3-Pinanediol is a critical component in modern pharmaceutical synthesis. By focusing on purity, reliability, and working with reputable manufacturers, procurement professionals can secure this vital intermediate and contribute to the successful development and production of essential medicines.