For chemical manufacturers engaged in the production of fine chemicals, pharmaceuticals, or specialty materials, the consistent availability of high-quality intermediates is non-negotiable. 2-Fluoroaniline, a compound designated by CAS number 348-54-9, is a prime example of such a vital intermediate. This article provides an in-depth look at its properties and offers practical guidance for chemical manufacturers on how to effectively source this compound to meet their production demands.

2-Fluoroaniline, with the molecular formula C6H6FN and a molecular weight of 111.12 g/mol, is characterized by its distinct chemical structure. As an ortho-substituted fluorinated aniline, it offers unique reactivity and properties that are leveraged across various synthesis pathways. The presence of the fluorine atom on the aromatic ring significantly influences the electronic characteristics and steric environment of the molecule. Physically, it is typically observed as a clear liquid, ranging in color from colorless to brown, depending on its purity and handling. Its boiling point is recorded at approximately 182-183 °C at standard pressure, and it possesses a flash point of around 60 °C, classifying it as a combustible liquid that requires careful handling.

The utility of 2-Fluoroaniline spans multiple sectors within the chemical industry. Its primary application is as a key intermediate in the synthesis of pharmaceuticals, where the incorporation of fluorine can enhance drug efficacy, bioavailability, and metabolic stability. It is also a valuable precursor in the manufacturing of agrochemicals, contributing to the development of more effective crop protection agents. Furthermore, its presence in the development of specialty chemicals, advanced polymers, and certain dyes underscores its versatility. For chemical manufacturers, understanding these applications is crucial for forecasting demand and identifying potential markets for products derived from 2-Fluoroaniline.

When it comes to sourcing 2-Fluoroaniline for manufacturing purposes, reliability and cost-effectiveness are paramount. Chemical manufacturers often seek direct relationships with producers to ensure stable supply chains and competitive pricing. China has become a dominant force in the global fine chemical market, with numerous manufacturers offering 2-Fluoroaniline (CAS 348-54-9) that meets international quality standards. When evaluating potential suppliers, manufacturers should scrutinize product specifications, purity levels (often 99% or higher), and the availability of Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS). It is also prudent to inquire about their production capacity, quality control processes, and logistical capabilities.

Manufacturers looking to purchase 2-Fluoroaniline should pay close attention to the terms of trade. Negotiating favorable Incoterms, such as FOB (Free On Board) or CIF (Cost, Insurance, and Freight), can significantly impact landed costs. Similarly, understanding payment terms, such as Letter of Credit (L/C) or Telegraphic Transfer (T/T), is vital for financial planning. Direct engagement with Chinese manufacturers can often lead to better pricing for bulk orders, especially when establishing long-term supply agreements. Additionally, exploring whether a supplier offers custom synthesis or toll manufacturing services can provide further flexibility for unique production requirements.

In summary, 2-Fluoroaniline (CAS 348-54-9) is a critical fine chemical intermediate with diverse applications, most notably in the pharmaceutical and agrochemical industries. Chemical manufacturers can optimize their procurement by understanding its properties, identifying reliable global suppliers, and carefully managing pricing and logistics. If your manufacturing operations require this essential compound, engaging with experienced manufacturers and suppliers is key to ensuring a seamless and cost-efficient supply chain.