In the sophisticated field of organic chemistry, particularly within the domain of peptide synthesis, understanding the properties and applications of specialized building blocks is fundamental. Boc-His(Bom)-OH, identified by CAS number 79950-65-5, is one such critical compound. This article provides an in-depth look at the chemical properties, synthesis considerations, and wide-ranging applications of this protected histidine derivative, aiming to inform researchers and procurement specialists about its significance as a high-quality chemical intermediate.

Boc-His(Bom)-OH is a derivative of the amino acid L-histidine, where both the alpha-amino group and the imidazole side chain are protected. The tert-butyloxycarbonyl (Boc) group is a commonly used protecting group for amines, stable under a variety of reaction conditions but readily removable under acidic conditions. The benzyloxymethyl (Bom) group is employed to protect the imidazole nitrogen, preventing its participation in unwanted reactions during peptide coupling. This specific combination of protecting groups makes Boc-His(Bom)-OH highly valuable in solid-phase peptide synthesis (SPPS) and other peptide construction methodologies. Its typical appearance is a white powder, and it exhibits good solubility in polar organic solvents such as dimethylformamide (DMF), dichloromethane (DCM), and methanol.

The synthesis of Boc-His(Bom)-OH involves carefully controlled reactions to introduce the Boc and Bom protecting groups onto the histidine molecule. While detailed proprietary synthesis routes vary among manufacturers, the objective is always to achieve high purity and yield. Researchers looking to buy Boc-His(Bom)-OH will often seek products that have undergone rigorous quality control, including techniques like High-Performance Liquid Chromatography (HPLC) for purity assessment and Nuclear Magnetic Resonance (NMR) spectroscopy for structural confirmation.

The applications of Boc-His(Bom)-OH are primarily centered around peptide synthesis. It serves as an essential precursor for incorporating histidine residues into peptide chains. Histidine's imidazole ring can act as a nucleophile, base, or metal ligand, playing vital roles in enzyme active sites and protein-ligand interactions. By using Boc-His(Bom)-OH, chemists can precisely control when and how this functional side chain is introduced, enabling the synthesis of peptides with specific biological activities. These peptides find applications in various sectors, including pharmaceuticals (drug development), diagnostics, and academic research.

For procurement managers and researchers, selecting a reliable supplier for Boc-His(Bom)-OH is crucial. Factors such as consistent product quality, competitive pricing, and dependable delivery schedules are key. As a manufacturer, we are committed to providing high-purity Boc-His(Bom)-OH that meets the exacting standards of the scientific community. We understand the importance of this intermediate in your projects, whether they are focused on drug discovery, biomaterial development, or fundamental chemical research. Exploring our offerings can provide you with a dependable source for this critical building block.