Diethyl (tosyloxy)methylphosphonate, identified by CAS number 31618-90-3, is a significant organic compound within the chemical industry, particularly recognized for its role as a pharmaceutical intermediate. Its molecular formula, C12H19O6PS, and molecular weight of 322.31 indicate a specific molecular structure that lends itself to complex synthetic pathways.

Physically, Diethyl (tosyloxy)methylphosphonate is described as a clear, colorless to pale yellow oily liquid. Its properties include a density of 1.255 and a refractive index typically between 1.4980 and 1.5020. While its boiling point at atmospheric pressure is high, it can be distilled under reduced pressure. Storage recommendations often suggest keeping it in a cool, ventilated place or under an inert atmosphere at 2-8°C to maintain its stability and purity.

The primary application that has brought Diethyl (tosyloxy)methylphosphonate to prominence is its use as a critical intermediate in the synthesis of Tenofovir. Tenofovir is a highly effective nucleotide analogue reverse transcriptase inhibitor (NtRTI) used extensively in the treatment of HIV/AIDS. The precise chemical transformations involving this compound are vital for building the complex structure of Tenofovir, making its availability and quality crucial for pharmaceutical manufacturers.

Beyond its direct role in Tenofovir synthesis, Diethyl (tosyloxy)methylphosphonate also functions as a phosphorylating agent. This property opens avenues for its application in other organic synthesis reactions where the introduction of a phosphoryl group is required. Researchers and chemists looking to buy this versatile intermediate for various synthetic projects can rely on specialized chemical suppliers who guarantee product integrity.

The synthesis of Diethyl (tosyloxy)methylphosphonate itself typically involves reactions with compounds such as diethyl hydroxymethylphosphonate and p-toluenesulfonyl chloride. Understanding these synthetic routes is important for both manufacturers aiming for efficient production and end-users who need to ensure the quality and source of their chemical inputs. For those seeking a reliable manufacturer and supplier of Diethyl (tosyloxy)methylphosphonate, exploring options that provide detailed technical data and consistent product specifications is essential.

In summary, Diethyl (tosyloxy)methylphosphonate is more than just a chemical compound; it's a gateway to essential antiviral therapies. As a key Tenofovir intermediate, its consistent supply and high purity are vital for global health initiatives. If you are involved in pharmaceutical manufacturing or advanced chemical research and need to purchase this intermediate, consider partnering with experienced suppliers who prioritize quality and reliability.