For synthetic chemists, the choice of protected amino acids is fundamental to the success of peptide synthesis. Fmoc-Lys(Boc)-OH, with its well-defined protective groups, is a workhorse reagent in modern Solid-Phase Peptide Synthesis (SPPS). This article offers a chemist's perspective on why this specific lysine derivative is so widely adopted and what makes it an indispensable tool in the lab. We’ll also touch upon the importance of sourcing from reputable manufacturers.

From a chemical standpoint, Fmoc-Lys(Boc)-OH, or N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyloxycarbonyl-L-lysine (CAS 71989-26-9), offers a balanced approach to incorporating lysine into peptide chains. The alpha-amino group is protected by the Fmoc moiety, which is readily removed by mild bases like piperidine. This deprotection step is crucial for the next coupling reaction. The side chain of lysine possesses a primary amine, and protecting this group is vital to prevent it from reacting during peptide chain elongation. The tert-butyloxycarbonyl (Boc) group is an excellent choice for this purpose due to its acid lability. This orthogonality means the Boc group can withstand the basic conditions used for Fmoc removal but is efficiently cleaved during the final acidic workup (typically using TFA), alongside the cleavage of the peptide from the resin. This dual protection strategy ensures that lysine residues are incorporated specifically as desired, leading to cleaner reaction profiles and higher yields of target peptides.

When chemists consider where to buy Fmoc-Lys(Boc)-OH, purity is always a primary concern. Impurities can lead to the formation of undesired byproducts, such as deletion sequences or modified lysine residues, which complicate purification and can reduce the yield of the target peptide. Therefore, selecting a product with a high purity, often specified as >99% by HPLC, is critical. This is why working with trusted suppliers who provide comprehensive analytical data, like detailed HPLC and NMR spectra, is essential for chemists. The CAS number (71989-26-9) is a standard reference point for ensuring product identity.

The practicality of using Fmoc-Lys(Boc)-OH also extends to its handling and stability. While it is a solid powder, proper storage conditions (typically refrigerated at 2-8°C) help maintain its integrity. For chemists undertaking complex synthesis projects, reliable availability is also a factor. Sourcing from a well-established manufacturer in China can ensure a consistent supply at competitive price points, allowing researchers to focus on the chemistry rather than on supply chain anxieties. Whether for academic research, drug discovery, or the synthesis of custom peptides, Fmoc-Lys(Boc)-OH remains a highly valued reagent.

We encourage all chemists and laboratory managers to consider our high-quality Fmoc-Lys(Boc)-OH for their synthesis needs. By partnering with a reliable supplier, you ensure the efficiency and success of your peptide synthesis endeavors.