For professionals in research and development (R&D) and chemical manufacturing, understanding the detailed specifications of key chemical intermediates is fundamental to project success. Fmoc-N-methyl-O-tert-butyl-L-tyrosine (CAS: 133373-24-7), known widely in the industry as Fmoc-N-Me-Tyr(tBu)-OH, is a specialized amino acid derivative with critical applications in peptide synthesis and pharmaceutical development. As a prominent manufacturer and supplier, we aim to provide a comprehensive overview of this compound's specifications and its importance for B2B clients.

Fmoc-N-Me-Tyr(tBu)-OH is a synthetically derived building block designed for advanced peptide synthesis methodologies. Its core structure features the amino acid tyrosine, modified with an Fmoc protecting group on the alpha-amino nitrogen, a methyl group also on the alpha-nitrogen, and a tert-butyl ether protecting group on the phenolic hydroxyl of the tyrosine side chain. The Fmoc group is a stable protecting group that is readily removed under mild basic conditions, making it highly compatible with standard solid-phase peptide synthesis (SPPS) protocols. The N-methyl group can influence peptide conformation and receptor binding, while the O-tert-butyl group ensures the phenolic hydroxyl remains unreactive during coupling steps.

Key specifications that R&D scientists and procurement managers should scrutinize include purity, appearance, and physical properties. Our Fmoc-N-Me-Tyr(tBu)-OH is consistently supplied with a purity of ≥98.0% (often determined by HPLC), ensuring minimal interference from impurities in sensitive synthesis reactions. The appearance is typically a white powder, indicative of its purified state. Other important parameters, such as molecular formula (C29H31NO5) and molecular weight (473.560), are critical for stoichiometric calculations in synthesis planning.

The applications of Fmoc-N-Me-Tyr(tBu)-OH are primarily centered around its role as a pharmaceutical intermediate and a reagent in peptide synthesis. It is instrumental in constructing peptides with modified structures, which can lead to enhanced biological activity, improved metabolic stability, or novel therapeutic properties. This makes it highly sought after in drug discovery programs aimed at developing peptide-based therapeutics. When considering where to buy this compound, prioritizing a reliable supplier that can provide consistent quality and documentation (like Certificates of Analysis) is paramount. We encourage inquiries for bulk quantities to obtain the most competitive price and ensure a stable supply for manufacturing needs. Requesting a quote is the first step to secure this essential material.

For manufacturing operations, the consistent availability of high-purity Fmoc-N-Me-Tyr(tBu)-OH is crucial for maintaining production yields and meeting stringent quality standards. As a dedicated manufacturer, we understand the importance of process scalability and cost-effectiveness. By optimizing our production and supply chain, we strive to offer a superior value proposition to our B2B partners.

In conclusion, Fmoc-N-methyl-O-tert-butyl-L-tyrosine is a sophisticated chemical building block with precise specifications tailored for demanding applications in peptide synthesis and pharmaceutical R&D. We invite you to partner with us, a trusted supplier and manufacturer, to purchase this essential derivative. Contact us today to receive a quote and ensure the quality and reliability of your chemical supply.