In the complex world of pharmaceutical research and development, understanding the behavior and impact of drug metabolites is paramount. One such crucial compound is N-Desmethyl Imatinib, identified by its CAS number 404844-02-6. This substance is not merely a byproduct of drug metabolism; it is a key active metabolite of Imatinib, a groundbreaking medication widely used in the treatment of various cancers, most notably chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST).

Imatinib itself is a targeted therapy, specifically inhibiting tyrosine kinases like Bcr-ABL, PDGFR, and KIT. When the body processes Imatinib, N-Desmethyl Imatinib is formed through a process called demethylation, primarily mediated by the cytochrome P450 enzyme CYP3A4. While Imatinib itself is the primary therapeutic agent, its metabolites, including N-Desmethyl Imatinib, can also exhibit pharmacological activity. In fact, N-Desmethyl Imatinib has demonstrated comparable in vitro potency at the Bcr-ABL kinase as Imatinib itself. This highlights its significance not just as a marker of drug processing, but as a potentially contributing factor to the overall therapeutic effect or even side effect profile of Imatinib.

For pharmaceutical scientists, researchers, and product formulators, sourcing high-quality N-Desmethyl Imatinib is essential. It serves multiple critical roles:

  • As a Pharmaceutical Reference Standard: In quality control laboratories, N-Desmethyl Imatinib is used to accurately identify and quantify this metabolite in Imatinib formulations or biological samples. This ensures the purity and efficacy of the final drug product.
  • In Drug Metabolism and Pharmacokinetic (DMPK) Studies: Researchers employ N-Desmethyl Imatinib to understand how Imatinib is processed in the body, how long it remains active, and how it is eliminated. This knowledge is vital for optimizing drug dosages and predicting potential drug-drug interactions.
  • As a Research Chemical: For academic and industrial researchers investigating tyrosine kinase inhibitors, cancer biology, or drug resistance mechanisms, N-Desmethyl Imatinib provides a valuable tool for experimentation.

As a leading chemical manufacturer and supplier based in China, we are committed to providing researchers and pharmaceutical companies with reliable access to high-purity N-Desmethyl Imatinib. We understand the critical nature of these compounds for drug development and clinical research. Therefore, we ensure that our N-Desmethyl Imatinib is produced under strict quality control measures, meeting the high standards demanded by the pharmaceutical industry. If you are looking to buy N-Desmethyl Imatinib or seeking a dependable supplier of N-Desmethyl Imatinib in China, we offer competitive pricing and consistent availability. We can fulfill orders for both research quantities and bulk pharmaceutical intermediate requirements. Our goal is to be your trusted partner in procuring essential chemical compounds, supporting your endeavors to advance cancer therapies and other critical pharmaceutical innovations. Contact us today to get a quote for your N-Desmethyl Imatinib needs and secure a robust supply chain.