Pioglitazone hydrochloride is a cornerstone medication in the management of type 2 diabetes, belonging to the thiazolidinedione class of drugs. Its efficacy relies heavily on the precise synthesis of its core chemical structure. At the heart of this process lies a critical intermediate: 5-Ethyl-2-pyridineethanol (CAS: 5223-06-3). For pharmaceutical manufacturers and R&D scientists, understanding the properties and sourcing of this pyridine derivative is essential for successful production. This article details its importance and how to procure it from a reliable source.

The Chemical Backbone: 5-Ethyl-2-pyridineethanol
5-Ethyl-2-pyridineethanol, chemically identified by its CAS number 5223-06-3, is a heterocycle featuring a pyridine ring substituted with an ethyl group at the 5-position and a 2-hydroxyethyl group at the 2-position. Its molecular formula is C9H13NO, and it possesses a molecular weight of 151.206. Typically supplied as a white to light yellow crystal, its high purity (≥99.0%) and low moisture content (≤0.5%) are critical attributes for its role in complex pharmaceutical syntheses. These characteristics ensure that it participates effectively in the subsequent reaction steps required to form Pioglitazone hydrochloride.

The Synthesis Pathway: A Critical Intermediate's Contribution
While specific proprietary synthesis routes vary, 5-Ethyl-2-pyridineethanol serves as a key building block in the multi-step process leading to Pioglitazone hydrochloride. The pyridine ring and the functionalized side chain provide the foundational elements that are further modified through various chemical reactions, such as condensation, cyclization, and salt formation. The quality of the 5-Ethyl-2-pyridineethanol used directly impacts the yield, purity, and overall efficiency of the Pioglitazone synthesis. Manufacturers seeking to buy this intermediate must prioritize suppliers who can guarantee consistent quality and chemical integrity.

Key Properties for Pharmaceutical Applications:

  • High Assay (≥99.0%): Ensures minimal unwanted side reactions and higher yields of the target API.
  • Low Moisture Content (≤0.5%): Prevents hydrolysis and other moisture-sensitive side reactions that could degrade product quality.
  • Defined Physical State: Available as a crystal, facilitating handling and accurate dosing in manufacturing processes.
  • Stable Storage Conditions: Recommended to be stored in a cool, ventilated place, preserving its chemical integrity over time.

Sourcing High-Quality 5-Ethyl-2-pyridineethanol
For companies that need to purchase 5-Ethyl-2-pyridineethanol for Pioglitazone hydrochloride production, NINGBO INNO PHARMCHEM CO.,LTD. stands as a reliable manufacturer and supplier. We understand the critical nature of pharmaceutical intermediates and are committed to providing products that meet rigorous quality standards. Our efficient manufacturing processes, coupled with strict quality control measures, ensure that you receive a consistently pure and reliable intermediate. We offer competitive pricing and can cater to various order sizes, from R&D quantities to commercial bulk purchases.

Partner with a Trusted Manufacturer
Ensuring the quality of your raw materials is fundamental to the success of your pharmaceutical manufacturing. If you are in the market to buy 5-Ethyl-2-pyridineethanol, consider partnering with NINGBO INNO PHARMCHEM CO.,LTD. We are dedicated to supporting the pharmaceutical industry with high-quality intermediates. Contact us for a quote and detailed product information.