In the intricate field of organic synthesis, the selection of appropriate building blocks and intermediates can significantly influence the efficiency, yield, and ultimate success of a chemical process. 2,3,4,5,6-Pentafluoroaniline, identified by CAS number 771-60-8, is a compound whose unique properties make it a sought-after intermediate for a variety of complex syntheses, particularly in the pharmaceutical and material science sectors. As a leading chemical supplier, we aim to provide a comprehensive understanding of why this compound is so valuable.

The molecular structure of 2,3,4,5,6-Pentafluoroaniline, with the formula C6H2F5N and a molecular weight of 183.08 g/mol, is defined by an aniline core heavily substituted with five fluorine atoms. This extensive fluorination is the source of many of its advantageous properties. Fluorine's high electronegativity significantly impacts the electron distribution within the molecule. It deactivates the aromatic ring towards electrophilic substitution while also influencing the basicity of the amino group, making it a much weaker base than unsubstituted aniline. This electronic modulation is crucial for specific synthetic transformations.

Physicochemical properties are critical for chemists when selecting an intermediate. 2,3,4,5,6-Pentafluoroaniline typically presents as a white crystal with a melting point in the range of 33-35°C, and a boiling point of approximately 153°C. Its solubility profile is also important; it is generally insoluble in water but soluble in many organic solvents such as toluene, methanol, and acetone. These characteristics facilitate its handling, purification, and use in various reaction media. For manufacturers looking to buy this intermediate, these predictable properties ensure ease of integration into their production workflows.

The high purity, often exceeding 99.0%, of 2,3,4,5,6-Pentafluoroaniline is a non-negotiable requirement for many advanced applications. In pharmaceutical synthesis, even minor impurities can lead to side reactions or affect the efficacy and safety of the final drug product. Similarly, in the development of liquid crystals or other advanced materials, the precise molecular structure and purity of the intermediate dictate the performance characteristics of the end product. This is why partnering with a reliable manufacturer and supplier is so important.

The utility of 2,3,4,5,6-Pentafluoroaniline extends to its role as a precursor in synthesizing various specialized compounds, including catalysts and intermediates for agrochemicals and polymers, though its primary commercial use remains in pharmaceuticals and liquid crystals. For procurement specialists and research scientists, understanding these properties allows for more informed decisions regarding its application and sourcing. We encourage those interested in purchasing this versatile intermediate to contact us for detailed specifications, pricing, and sample requests, ensuring your chemical synthesis projects are supported by quality materials.