In the intricate world of pharmaceutical synthesis, the precise selection of chemical intermediates is critical for developing effective and safe medications. 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose, identified by its CAS number 21740-23-8, is a prime example of such an indispensable compound. Primarily recognized for its role as a precursor in the synthesis of Decitabine, this intermediate's chemical and physical properties make it highly valuable for advanced organic synthesis and pharmaceutical R&D.

Let's examine the key characteristics that make this compound a preferred choice for researchers and manufacturers. The typical appearance is an off-white powder, indicating a solid form that is convenient for weighing and handling in laboratory and production settings. Its molecular formula, C19H15Cl3O5, and a molecular weight of approximately 429.68 g/mol, provide essential data for stoichiometric calculations in synthesis. Crucially, its assay purity is generally guaranteed to be ≥90.0%, ensuring a high concentration of the active compound and minimizing potential interference from impurities during complex reactions.

Further crucial specifications include a low loss on drying (≤2.0%), which signifies minimal residual moisture, and a residue on ignition of ≤2.0%, indicating low levels of inorganic contaminants. These parameters are vital for ensuring the stability and reactivity of the compound. While specific storage conditions can vary by supplier, it is often recommended to store such intermediates in a cool, dry place, sometimes under inert atmosphere, to maintain optimal integrity and prevent degradation, especially given its potential instability in solution as noted by some sources.

The primary application for 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose is its function as a key intermediate in the synthesis of Decitabine. Decitabine is an epigenetic drug used in cancer therapy, and the reliable supply of its precursor is fundamental for its production. Beyond this well-established use, the compound's structure lends itself to the creation of a wide range of nucleoside analogs. These analogs are extensively explored for their potential as antiviral agents, anticancer drugs, and tools in biochemical research, probing cellular mechanisms and DNA-related processes.

For professionals seeking to buy this vital intermediate, understanding these properties is key to making informed purchasing decisions. It is advisable to source from reputable manufacturers and suppliers that provide detailed specifications and Certificates of Analysis (CoA). Considering factors like competitive price and availability for bulk orders is also essential for efficient procurement. Engaging with a reliable supplier in China or other established chemical manufacturing regions can provide access to high-quality materials that meet stringent pharmaceutical standards.

In essence, 1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose is a cornerstone chemical for advancements in pharmaceutical research and development. Its well-defined properties and critical role in producing life-saving medications underscore the importance of securing a consistent and high-quality supply. By understanding its characteristics and applications, researchers and manufacturers can better identify the right partners to purchase this essential intermediate.