For chemists and researchers in the fields of pharmaceuticals, agrochemicals, and specialty materials, understanding the fundamental properties and synthesis routes of key intermediates is crucial for successful R&D. 2,3-Difluoroaniline (CAS 4519-40-8) is one such compound, offering unique chemical characteristics that enable innovative discoveries. As a dedicated 2,3-Difluoroaniline manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides insight into this valuable organic intermediate.

Key Properties of 2,3-Difluoroaniline

2,3-Difluoroaniline is typically presented as a clear light orange liquid. Its chemical structure, C6H5F2N, features a benzene ring substituted with two fluorine atoms at the 2 and 3 positions. This difluorination significantly influences its chemical behavior and physical properties:

  • Molecular Weight: 129.11 g/mol
  • Boiling Point: Approximately 68-69 °C (at specific pressures, e.g., 12 mmHg).
  • Flash Point: Around 71 °C, indicating a moderate flammability risk.
  • Purity: High purity levels, often exceeding 99.5%, are standard for demanding applications.

The presence of fluorine atoms enhances the compound's reactivity in certain reactions, improves its lipophilicity, and can contribute to increased metabolic stability in biological systems. These attributes make it a highly sought-after building block for complex molecular designs.

Synthesis Routes for 2,3-Difluoroaniline

The industrial synthesis of 2,3-Difluoroaniline typically involves multi-step processes. A common approach begins with readily available precursors like 2,3-dichloronitrobenzene. Key stages often include:

  1. Fluorination: Introducing fluorine atoms into the aromatic ring.
  2. Reduction: Converting a nitro group (-NO2) to an amino group (-NH2).

One established method involves the reduction of 2,3-difluoronitrobenzene, often utilizing palladium catalysts in the presence of hydrogen and a base like triethylamine. Other routes may involve direct fluorination of aniline derivatives or sequential reactions that build the desired fluorinated aromatic structure. For R&D professionals looking to buy 2,3-Difluoroaniline, understanding these synthesis pathways can provide context for quality expectations and potential impurities.

Why Source from a Trusted Manufacturer?

To ensure successful research and development, it is critical to purchase 2,3-Difluoroaniline from a reliable 2,3-Difluoroaniline supplier. A reputable 2,3-Difluoroaniline manufacturer guarantees not only the specified purity but also the consistency required for reproducible experimental results. Factors such as competitive 2,3-Difluoroaniline price and consistent availability are also vital for R&D budgets and timelines. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with high-quality intermediates, backed by technical expertise and responsive customer service. We are your go-to source for this essential building block.