For chemists and procurement specialists in the fine chemical and pharmaceutical sectors, a thorough understanding of key intermediates is vital. 3-Bromo-9H-fluoren-9-one, identified by CAS number 2041-19-2, is a compound that warrants detailed examination due to its utility in various synthetic pathways. This article provides insights into its properties, synthesis, and the advantages of sourcing it from reliable manufacturers.

Chemical and Physical Properties

3-Bromo-9H-fluoren-9-one is an organic compound with the molecular formula C13H7BrO and a molecular weight of approximately 259.10 g/mol. Its structure features a fluorene ring system substituted with a bromine atom at the 3-position and a carbonyl group at the 9-position. This unique arrangement of functional groups imparts specific reactivity, making it a valuable intermediate in organic synthesis. It is typically presented as a light yellow powder, with a melting point range of 188-190°C, indicating its solid state at room temperature.

The compound's key chemical properties include:

  • Reactivity: The bromine atom is susceptible to nucleophilic substitution and coupling reactions (e.g., Suzuki, Sonogashira), while the carbonyl group can undergo various reduction and addition reactions.
  • Stability: Generally stable under recommended storage conditions (dry, well-ventilated area), it is crucial to handle it with appropriate safety measures.
  • Purity: For its intended applications, especially in pharmaceutical synthesis, high purity (typically 97% min) is essential. Buyers should always verify the purity specifications from their suppliers.

Synthesis and Manufacturing Considerations

The synthesis of 3-Bromo-9H-fluoren-9-one typically involves bromination of fluoren-9-one or related precursors. Developing efficient and scalable synthesis routes is a focus for chemical manufacturers aiming to provide this compound at a competitive price. When considering where to buy this intermediate, engaging with a reputable manufacturer in China often provides access to cost-effective production capabilities and expertise in handling such syntheses.

Key considerations for manufacturers include:

  • Optimized Reaction Conditions: Ensuring high yields and minimal by-products through precise control of reaction parameters.
  • Purification Techniques: Implementing effective purification methods to achieve the required purity standards for pharmaceutical and fine chemical applications.
  • Quality Control: Robust quality control measures are necessary throughout the production process.

Conclusion

3-Bromo-9H-fluoren-9-one (CAS 2041-19-2) is a compound of considerable utility in organic chemistry. Understanding its properties and the factors influencing its synthesis and supply is crucial for scientists and procurement professionals. By partnering with reliable suppliers and manufacturers, and prioritizing product purity and competitive pricing, organizations can effectively leverage this intermediate for their critical R&D and production needs.