For scientists and product formulators in the pharmaceutical and chemical research sectors, understanding the nuances of key intermediates is fundamental to innovation. (R)-1-Benzylpiperidin-3-ol, identified by its CAS number 91599-81-4, stands out as a versatile and valuable chiral building block. This article aims to provide a comprehensive overview of its properties and significant applications, assisting you in your research endeavors and procurement decisions.

Physically, (R)-1-Benzylpiperidin-3-ol is typically described as a liquid, often appearing in shades of light orange to yellow or green. Its molecular weight is approximately 191.27 g/mol. Key physical properties that are crucial for handling and formulation include its boiling point of around 275°C and a density of 1.07 g/mL at 25°C. Its refractive index is noted at 1.547. These specifications are critical for researchers when planning experimental setups and analytical procedures.

The primary utility of (R)-1-Benzylpiperidin-3-ol lies in its role as a pharmaceutical intermediate. Its chiral nature makes it particularly important in the synthesis of stereospecific drugs, where the precise three-dimensional arrangement of atoms dictates biological activity. One notable application is its use in the preparation of in vivo probes designed for measuring endogenous acetylcholine levels. This capability is invaluable for neurological research and the study of neurotransmitter systems.

Beyond its specific use in acetylcholine probes, this compound exhibits hypotensive effects, indicating potential applications in cardiovascular research or as a precursor for antihypertensive agents. As a benzylpiperidine derivative, it offers a versatile scaffold for medicinal chemists exploring new therapeutic entities. Researchers looking to buy this compound for early-stage drug discovery will find its structure amenable to various derivatizations.

For those in the market to purchase (R)-1-Benzylpiperidin-3-ol, sourcing from reputable manufacturers and suppliers is key. Purity levels, often specified as 95% or higher, are critical for ensuring reliable experimental results and downstream synthesis success. When you decide to purchase, consider suppliers who provide comprehensive technical data, including Certificates of Analysis (COA), and ensure clear communication regarding lot-to-lot consistency. For example, inquiring about specific optical activity, such as [α]24/D 12° in methanol, can be important for chiral applications.

In summary, (R)-1-Benzylpiperidin-3-ol is more than just a chemical; it's a key enabler for advanced research. Whether you are synthesizing novel APIs or developing sophisticated diagnostic tools, understanding its properties and applications will guide your selection of this essential chemical intermediate. We encourage you to reach out to experienced chemical suppliers for your sourcing needs.