For professionals in the chemical and pharmaceutical industries, precise technical specifications are fundamental to successful research, development, and manufacturing. Rosuvastatin Methyl Ester (CAS 147118-40-9), a vital intermediate in the production of the blockbuster drug Rosuvastatin Calcium, is no exception. Understanding its detailed specifications ensures that procurement decisions are informed and that the material is suitable for its intended, often highly sensitive, applications.

Chemical Identity and Properties

Product Name: Rosuvastatin Methyl Ester
CAS Number: 147118-40-9
Molecular Formula: C23H30FN3O6S
Molecular Weight: Approximately 495.56 g/mol

These identifiers are the first critical pieces of information for any chemist or procurement specialist. They confirm the exact chemical compound being discussed and provide a basis for all subsequent quality assessments.

Key Specifications for Rosuvastatin Methyl Ester

When you are looking to buy or source Rosuvastatin Methyl Ester, several key specifications are consistently highlighted by manufacturers and suppliers:

  • Appearance: Typically described as a 'White to Off-White Crystalline Powder'. Deviations from this can indicate potential issues with purity or degradation.
  • Purity/Assay: This is arguably the most critical specification for a pharmaceutical intermediate. Reputable suppliers will offer Rosuvastatin Methyl Ester with a high assay, commonly stated as '≥ 99.0%' or '≥ 99.5%'. This high level of purity is essential to minimize impurities in the final API.
  • Identification: Methods like Infrared (IR) spectroscopy or Nuclear Magnetic Resonance (NMR) are used to confirm the identity of the compound, ensuring it matches the expected structure. Manufacturers will usually state that it 'Meets to the requirements' for identification.
  • Melting Point: The reported melting point range for Rosuvastatin Methyl Ester is typically between 72.0 ~ 78.0℃. This physical property serves as another indicator of purity.
  • Loss on Drying (LOD): A low LOD, often specified as '≤ 0.5%', is important to ensure the absence of residual solvents or moisture, which could affect stability and reactivity.
  • Related Substances/Impurities: Manufacturers will often specify limits for single impurities (e.g., '≤ 1.0%') and total impurities (e.g., '≤ 3.0%'). Control over these parameters is vital for meeting regulatory requirements.
  • Specific Rotation: Given the chiral nature of the molecule, specific rotation values (e.g., '+20°~ +28°') are important for confirming the correct stereochemistry, which is crucial for biological activity.

Usage and Applications

The primary usage of Rosuvastatin Methyl Ester is as a key intermediate in the synthesis of Rosuvastatin Calcium. It is also valuable as a reference standard for impurity profiling in pharmaceutical quality control. For research and development purposes, having access to well-characterized materials like this is fundamental for developing new analytical methods or exploring novel synthetic routes.

Procurement Considerations

When purchasing Rosuvastatin Methyl Ester, always verify that the supplier provides comprehensive documentation that aligns with these specifications. Understanding these details empowers chemists, R&D scientists, and procurement managers to make informed decisions, ensuring the quality and consistency required for successful pharmaceutical manufacturing. If you are seeking to buy this important intermediate, look for manufacturers who prioritize these detailed specifications.