4-Chloro-N-methylpicolinamide, identified by CAS 220000-87-3, is a complex organic compound that plays a vital role in various chemical synthesis pathways. As a key intermediate, its unique chemical structure lends itself to significant applications, particularly within the pharmaceutical and agrochemical sectors. For professionals involved in research, development, and manufacturing, a thorough understanding of its properties and uses is essential for optimizing synthetic processes and product development.

Chemically, 4-Chloro-N-methylpicolinamide is characterized by a pyridine ring substituted with a chlorine atom and a carboxamide group bearing a methyl substituent. This arrangement of functional groups imparts specific reactivity, making it a valuable building block in organic synthesis. Its physical properties typically include an off-white to pale yellow crystalline powder appearance, a melting point in the range of 41-43°C, and a boiling point around 317.8°C. These characteristics are crucial for handling, storage, and integration into various reaction chemistries.

The primary application driving demand for 4-Chloro-N-methylpicolinamide is its role as an intermediate in the synthesis of Sorafenib. Sorafenib is a significant anti-cancer drug used to treat advanced renal cell carcinoma and hepatocellular carcinoma. The precise chemical transformations involving this intermediate are critical for constructing the active pharmaceutical ingredient (API). Therefore, sourcing high-purity 4-Chloro-N-methylpicolinamide from reputable manufacturers, such as those who operate within China's robust chemical industry, is a prerequisite for successful pharmaceutical production.

Beyond its critical pharmaceutical application, this compound also finds utility in broader organic synthesis. Researchers may utilize it to create novel pyridine derivatives with potential applications in medicinal chemistry, materials science, or as specialized reagents. For those looking to buy 4-Chloro-N-methylpicolinamide for research purposes, understanding its reactivity profile allows for the exploration of new synthetic routes and the development of innovative chemical products. A dependable supplier can provide not only the material but also essential documentation like Safety Data Sheets (SDS) and Certificates of Analysis (CoA), supporting safe and effective use.

In conclusion, 4-Chloro-N-methylpicolinamide is a strategically important chemical intermediate. Its value is amplified by its role in life-saving pharmaceuticals and its versatility in organic synthesis. By partnering with established chemical manufacturers, researchers and production facilities can ensure a consistent and high-quality supply, driving advancements in drug development and chemical innovation. When considering your next chemical procurement, remember the significance of this compound and the importance of reliable sourcing for your critical projects.