For chemists and formulation scientists, a thorough understanding of a chemical intermediate's properties is fundamental to successful synthesis and application. 4-Fluorophenylacetonitrile, also known as p-Fluorobenzyl cyanide (CAS 459-22-3), is a prime example of such a compound, offering a unique blend of reactivity and stability essential for creating complex molecules.

At its core, 4-Fluorophenylacetonitrile is an aromatic nitrile featuring a fluorine atom substituted on the phenyl ring at the para position. Its molecular formula is C8H6FN, with a molecular weight of 135.14 g/mol. The compound typically presents as a colorless to pale yellow liquid, with a purity usually exceeding 98% as determined by Gas Chromatography (GC). This high purity is a critical factor for its use in sensitive synthetic processes, ensuring minimal side reactions and predictable outcomes.

The key to its synthetic utility lies in its functional groups. The nitrile group (-CN) is electron-withdrawing and highly reactive. It can readily undergo hydrolysis to form 2-(4-fluorophenyl)acetic acid, reduction to yield 2-(4-fluorophenyl)ethylamine, or participate in various addition reactions, such as cyanation or cyclization. This versatility makes it an invaluable intermediate for building complex carbon skeletons and introducing nitrogen-containing functionalities into target molecules.

The fluorine atom on the aromatic ring also plays a significant role. Fluorine is the most electronegative element, and its presence can alter the electron distribution within the molecule. In the context of organic synthesis, fluorine substitution can influence the reactivity of nearby groups, affect the acidity or basicity of adjacent atoms, and importantly, enhance the lipophilicity and metabolic stability of derived compounds. This latter property is particularly advantageous in pharmaceutical and agrochemical applications, where improved bioavailability and resistance to degradation are desired.

Regarding physical properties, 4-Fluorophenylacetonitrile has a boiling point around 210-212°C and a flash point of 92°C. It is soluble in common organic solvents like ethanol and ether but insoluble in water. These properties dictate its handling and storage requirements. For optimal shelf life and stability, it is recommended to store the compound under an inert atmosphere (N2/Ar) at refrigerated temperatures (2-8°C). Proper storage conditions are crucial for maintaining its purity and reactivity over time, typically up to 24 months.

For professionals looking to buy 4-Fluorophenylacetonitrile, understanding these chemical properties is key to selecting the right grade and sourcing from a reliable manufacturer. Whether for pharmaceutical synthesis, agrochemical development, or material science applications, ensuring that the sourced CAS 459-22-3 meets specific purity and stability requirements is paramount. Partnering with a reputable supplier that provides detailed technical data and support is highly recommended.