For chemists and researchers involved in organic synthesis, a thorough understanding of key intermediates is fundamental. 4-Bromoacetanilide (CAS 103-88-8) is one such compound, valued for its versatile reactivity and role as a building block in creating more complex organic structures. This article aims to provide essential information regarding its properties, synthesis, and applications, particularly for those looking to buy or source this chemical.

Chemically known as N-(4-Bromophenyl)acetamide, 4-Bromoacetanilide has the molecular formula C8H8BrNO and a molecular weight of 214.06. It is typically supplied as a white to beige or light gray crystalline powder, a characteristic that aids in its identification and handling. A critical parameter for users is its assay, which is generally stated as ≥98.0%. This high purity level is vital for ensuring predictable reaction outcomes and minimizing the introduction of unwanted byproducts in sensitive synthetic processes.

The synthesis of 4-Bromoacetanilide commonly involves the electrophilic aromatic substitution of acetanilide. The process usually begins with acetylation of aniline to protect the amine group and then proceeds with bromination, often using a bromine source in an acidic medium like acetic acid. While elemental bromine can be used, modern approaches may explore safer and more selective brominating agents to improve the process's environmental profile and safety, aligning with Green Chemistry principles. The typical melting point range for purified 4-Bromoacetanilide is between 165-169 °C, a key physical property for quality assessment.

The applications of 4-Bromoacetanilide are diverse, primarily centering around its role as an intermediate in organic synthesis. It is frequently employed in the preparation of dyes, pharmaceuticals, and agrochemicals. For instance, the bromo substituent can undergo further reactions, such as nucleophilic substitution or cross-coupling reactions (e.g., Suzuki, Heck couplings), allowing for the introduction of various functionalities or the construction of larger aromatic systems.

For procurement professionals and laboratory managers, understanding the sourcing landscape for 4-Bromoacetanilide is important. Identifying reliable manufacturers and suppliers, especially those based in China, can provide access to high-quality material at competitive prices. When you consider purchasing this intermediate, it's beneficial to inquire about the supplier’s quality control measures, their ability to provide detailed product specifications, and their capacity for timely delivery, whether for research quantities or bulk industrial needs.

In summary, 4-Bromoacetanilide (CAS 103-88-8) is a fundamental organic intermediate with significant utility. Its properties, typical synthesis routes, and diverse applications make it an indispensable compound in many chemical endeavors. We, as a dedicated manufacturer and supplier, are committed to providing high-purity 4-Bromoacetanilide. We invite you to contact us to learn more about our product offerings, obtain pricing, and discuss how we can meet your specific requirements for this essential chemical building block.