For any procurement professional in the pharmaceutical sector, a deep understanding of the materials they source is critical. 2-Phenylisobutyric Acid (CAS 826-55-1), a key intermediate, is no different. Beyond its chemical name, grasping its specifications – purity, appearance, and other physical properties – is essential for ensuring successful API synthesis and product quality.

The Importance of Purity

The primary specification that buyers look for when they want to buy 2-Phenylisobutyric Acid is its purity. In pharmaceutical applications, even minor impurities can have significant downstream effects, potentially impacting reaction yields, product efficacy, and safety profiles. Manufacturers typically specify purity levels using methods like High-Performance Liquid Chromatography (HPLC). You will commonly see specifications such as ≥97% or ≥99.5%. For sensitive API syntheses, opting for the higher purity grade is often a prudent choice, despite a potentially higher initial price.

Appearance and Physical Properties: More Than Just Aesthetics

The typical appearance of 2-Phenylisobutyric Acid is a white crystalline powder. While this might seem like a minor detail, consistency in appearance can be an initial indicator of product quality and uniformity. Deviations from the expected color or form could suggest issues during manufacturing or storage. Other physical properties, like the melting point (80-82°C) and boiling point (270.5°C), are vital for process engineers who design reaction conditions. These parameters influence solubility, reaction kinetics, and isolation procedures.

What to Request from Your Supplier

When you are ready to purchase this intermediate, ensure your chosen supplier provides:

  • Certificate of Analysis (CoA): This document is non-negotiable. It should detail the actual test results for purity, appearance, moisture content, and any other critical specifications relevant to your application.
  • Material Safety Data Sheet (MSDS): Essential for safe handling, storage, and transportation information.
  • Batch-Specific Information: Knowing the batch number allows for traceability and easier troubleshooting if issues arise.
  • Consistent Quality: A reliable manufacturer will demonstrate consistency in their product specifications across different batches.

Choosing a partner who can consistently deliver 2-Phenylisobutyric Acid meeting these stringent specifications is crucial. If you are looking for a trustworthy supplier in China that prioritizes quality, consider engaging with experienced chemical manufacturers who can provide comprehensive documentation and support for your pharmaceutical intermediate needs.