Understanding the Reactivity of (S)-(-)-3-Cyclohexenecarboxylic Acid for Chemical Synthesis
For chemists and formulators engaged in fine chemical synthesis and pharmaceutical development, a deep understanding of the reactivity of key intermediates is essential. (S)-(-)-3-Cyclohexenecarboxylic Acid (CAS 5708-19-0) is one such compound, prized for its dual functional groups and defined stereochemistry. Its predictable chemical behavior makes it a reliable building block for creating a wide array of complex molecules.
The molecular structure of (S)-(-)-3-Cyclohexenecarboxylic Acid features a six-membered ring with a double bond between carbons 3 and 4, and a carboxylic acid group attached to a chiral carbon (C1). This combination dictates its reactivity. The carboxylic acid moiety can undergo standard reactions such as esterification with alcohols, amidation with amines, or conversion to acid halides and anhydrides. These transformations are fundamental for attaching the chiral cyclohexene scaffold to other molecular fragments or for modifying its properties.
The presence of the double bond within the ring also offers significant synthetic utility. It can participate in electrophilic addition reactions, such as halogenation or hydrohalogenation, or undergo cycloaddition reactions like the Diels-Alder reaction, provided suitable diene or dienophile partners are available. Furthermore, hydrogenation can convert the cyclohexene ring into a cyclohexane ring, altering the conformational properties of the molecule. These reactions allow chemists to expand the structural complexity derived from this intermediate.
When considering to buy (S)-(-)-3-Cyclohexenecarboxylic Acid, chemists often look for suppliers who can provide detailed characterization data, including typical reaction yields and conditions for common transformations. Manufacturers in China are a prime source for this intermediate, often supplying it at high purity (e.g., 99%). Understanding the cost-effectiveness and availability of this versatile intermediate from these suppliers can significantly impact research and production timelines. Exploring its reactivity further can unlock new synthetic pathways for innovative chemical products.
Perspectives & Insights
Silicon Analyst 88
“These transformations are fundamental for attaching the chiral cyclohexene scaffold to other molecular fragments or for modifying its properties.”
Quantum Seeker Pro
“The presence of the double bond within the ring also offers significant synthetic utility.”
Bio Reader 7
“It can participate in electrophilic addition reactions, such as halogenation or hydrohalogenation, or undergo cycloaddition reactions like the Diels-Alder reaction, provided suitable diene or dienophile partners are available.”