In the intricate world of organic chemistry, specific molecular structures serve as foundational elements for creating a vast array of complex compounds. 1-Bromo-4-fluorobutane (CAS 462-72-6) is one such versatile intermediate, widely utilized by chemists for its unique combination of reactive sites and its role in introducing fluorinated segments into organic molecules. Understanding its properties and applications is key for any chemist looking to expand their synthetic repertoire.

Chemical Properties and Reactivity
1-Bromo-4-fluorobutane is an alkyl halide characterized by a four-carbon chain bearing a bromine atom at one end and a fluorine atom at the other. This difunctional nature is its primary asset. The carbon-bromine bond is polar and susceptible to nucleophilic attack, making it an excellent substrate for SN2 reactions, alkylation of various nucleophiles (like amines, thiols, and carbanions), and formation of organometallic reagents such as Grignard reagents or organolithium compounds. The carbon-fluorine bond, in contrast, is one of the strongest single bonds in organic chemistry. While less reactive than the C-Br bond, the fluorine atom can still exert significant electronic effects on nearby functional groups and impart specific physical properties, such as increased lipophilicity and metabolic stability, to the molecules into which it is incorporated.

Synthetic Applications Across Disciplines
The utility of 1-bromo-4-fluorobutane spans across several key areas of organic synthesis:

  • Pharmaceutical and Agrochemical Synthesis: This intermediate is frequently employed in the synthesis of new drug candidates and crop protection agents. By introducing a fluorobutyl moiety, chemists can fine-tune pharmacokinetic properties, enhance efficacy, and improve the metabolic profile of target molecules. For example, its use in building fluorinated heterocycles is common.
  • Material Science: Fluorinated compounds often possess unique material properties, such as low surface energy and high thermal stability. 1-Bromo-4-fluorobutane can be used to synthesize fluorinated polymers or specialty materials with tailored characteristics.
  • Research and Development: As a readily available and reactive building block, it serves as a crucial starting material for exploratory synthesis in academic and industrial R&D settings, enabling the creation of novel organic structures.

Sourcing High-Quality 1-Bromo-4-fluorobutane
For researchers and manufacturers, securing a reliable source for 1-bromo-4-fluorobutane is essential for consistent experimental results and production. When you choose to buy this intermediate, consider a reputable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., a dedicated supplier in China. We ensure high purity (commonly available at 95%min, 97%, or 98.0+%) and offer competitive pricing, supporting your chemical research and development endeavors. Explore the potential of 1-Bromo-4-fluorobutane in your next synthesis project by partnering with a trusted chemical supplier.