In the dynamic field of chemical synthesis, the selection of appropriate building blocks can dramatically influence the efficiency and success of a project. 5-Bromo-2-iodopyrimidine (CAS 183438-24-6) has emerged as a compound of significant interest due to its versatile reactivity and its critical role in constructing complex molecular architectures, particularly within pharmaceutical research and development. This article highlights the advantages of using 5-Bromo-2-iodopyrimidine and provides insights for procurement managers and chemists looking to purchase this essential intermediate.

The Chemical Advantage: Dual Halogenation of 5-Bromo-2-iodopyrimidine

The molecular formula of 5-Bromo-2-iodopyrimidine is C4H2BrIN2, with a molecular weight of approximately 284.88 g/mol. The key to its synthetic utility lies in the strategic placement of both a bromine and an iodine atom on the pyrimidine ring. This dual halogenation offers chemists distinct advantages: differential reactivity in palladium-catalyzed cross-coupling reactions. The carbon-iodine bond is typically more reactive than the carbon-bromine bond under standard catalytic conditions. This allows for selective, sequential functionalization, enabling the stepwise introduction of different substituents. This precision is invaluable for synthesizing complex molecules, such as those found in advanced pharmaceuticals, where precise structural control is paramount for biological activity.

Applications Driving Demand for 5-Bromo-2-iodopyrimidine

The principal application for 5-Bromo-2-iodopyrimidine is as an intermediate in the synthesis of pharmaceuticals. It is frequently employed in the development of antiviral and anticancer agents, as well as compounds targeting various other therapeutic areas. Its ability to participate in Suzuki, Sonogashira, and other coupling reactions makes it an ideal precursor for creating diverse substituted pyrimidine structures that are common motifs in drug molecules. Beyond pharmaceuticals, its utility extends to the synthesis of specialty chemicals and materials, where its reactivity can be harnessed to create compounds with tailored electronic or physical properties. For any organization involved in cutting-edge chemical synthesis, securing a reliable supply of this intermediate is a strategic imperative.

Where to Buy: Partnering with Chinese Manufacturers and Suppliers

For procurement managers and chemists seeking to buy 5-Bromo-2-iodopyrimidine, identifying a trustworthy supplier is key. China is a major hub for the production of high-quality fine chemical intermediates. When looking for a manufacturer and supplier, it is essential to consider factors such as product purity (typically >97% or >99% by HPLC), consistency, scalability of production, and competitive pricing. A reputable supplier will provide comprehensive documentation, including Certificates of Analysis (COA), and maintain robust quality control systems. Establishing a relationship with a dependable supplier ensures a stable supply chain, which is critical for ongoing research and development projects or commercial manufacturing.

In conclusion, 5-Bromo-2-iodopyrimidine is a highly advantageous chemical intermediate, offering chemists unparalleled flexibility and control in synthesis. Its dual halogenation and participation in key cross-coupling reactions make it indispensable for developing the next generation of pharmaceuticals and advanced materials. By strategically sourcing from reliable Chinese manufacturers, businesses can secure the high-quality intermediate needed to drive innovation forward.