In the realm of chemical research, the availability of versatile and reactive intermediates is fundamental to scientific advancement. 5-Bromo-2-iodopyrimidine (CAS 183438-24-6) has established itself as a compound of considerable utility, particularly in the field of organic synthesis and pharmaceutical development. Its unique chemical structure and reactivity make it an indispensable tool for scientists engaged in creating novel molecules. This article provides an overview of 5-Bromo-2-iodopyrimidine, its applications, and guidance for researchers looking to purchase this essential intermediate from reliable sources.

The Chemical Profile of 5-Bromo-2-iodopyrimidine

With the molecular formula C4H2BrIN2 and a molecular weight of approximately 284.88 g/mol, 5-Bromo-2-iodopyrimidine is a dihalogenated pyrimidine. The strategic placement of a bromine atom at the 5-position and an iodine atom at the 2-position on the pyrimidine ring confers distinct reactive properties. This dual functionality is particularly advantageous in modern synthetic chemistry, where it enables precise, regioselective transformations. The differential reactivity between the carbon-iodine and carbon-bromine bonds is masterfully exploited in various palladium-catalyzed cross-coupling reactions, such as Suzuki and Sonogashira couplings.

Applications in Chemical Research and Development

The primary application domain for 5-Bromo-2-iodopyrimidine is as a building block in organic synthesis. Researchers frequently employ it in the development of pharmaceuticals, agrochemicals, and advanced materials. Its ability to undergo sequential cross-coupling reactions allows for the efficient construction of complex pyrimidine derivatives, which are common structural motifs in many biologically active compounds. In pharmaceutical research, this intermediate is vital for synthesizing potential antiviral agents, anticancer drugs, and other therapeutic molecules. For scientists aiming to explore new chemical space or optimize existing synthetic routes, 5-Bromo-2-iodopyrimidine offers a highly versatile platform.

Procurement Guidance for Researchers: Buying from China

For chemical researchers needing to buy 5-Bromo-2-iodopyrimidine, securing a high-quality product from a trustworthy supplier is paramount. China has become a global leader in the production of fine chemical intermediates, offering many reputable manufacturers and suppliers. When considering a purchase, it is essential to prioritize product purity, typically specified as >97% or >99% by HPLC. Reliability of supply, consistent batch quality, and competitive pricing are also crucial factors. Prospective buyers should always inquire about Certificates of Analysis (COA) to verify purity and consult Safety Data Sheets (SDS) for handling information. Establishing a relationship with a well-vetted Chinese manufacturer ensures that research projects can proceed without interruption due to intermediate quality or availability issues.

In conclusion, 5-Bromo-2-iodopyrimidine is a chemical intermediate of significant value for chemical research. Its unique reactivity, driven by its dual halogenation, makes it an essential component in the synthesis of complex organic molecules. By understanding its applications and opting for reliable suppliers, researchers can effectively leverage this powerful building block to drive scientific innovation forward.