Sodium thiosulfate (Na2S2O3) is an inorganic compound with a rich chemical profile that underpins its widespread applications. As a white crystalline solid, it is most commonly encountered as the pentahydrate, Na2S2O3·5H2O. Its physical properties include good solubility in water and a relatively low melting point of around 48°C for the pentahydrate. Chemically, sodium thiosulfate is recognized for its role as a reducing agent. The thiosulfate ion (S2O3^2-) contains sulfur atoms in different oxidation states, allowing it to readily donate electrons in redox reactions.

One of its characteristic reactions is with iodine, where it reduces iodine to iodide ions while being oxidized to tetrathionate ions. This reaction is fundamental to iodometric titrations, a common analytical chemistry technique used for quantifying oxidizing agents. The balanced ionic equation is 2S2O3^2- + I2 → S4O6^2- + 2I-. Sodium thiosulfate also reacts with acids, typically decomposing to form sulfur, sulfur dioxide, and water, a reaction that necessitates careful handling in acidic environments.

The preparation of sodium thiosulfate commonly involves reacting sodium sulfite with sulfur powder and heating the mixture, followed by filtration and crystallization. Alternatively, it can be produced from waste streams in chemical manufacturing. These preparation methods ensure a supply of this essential chemical for various industries.

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