Cosmetic Active Ingredients

Hexamidine Diisethionate

CAS No.659-40-5
GradeIndustrial / Pharmaceutical
Availability● In Stock

High-purity Hexamidine Diisethionate (CAS 659-40-5) is a next-generation cosmetic active ingredient with potent anti-dandruff and antipruritic properties, ideal for scalp and hair care formulations.

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Product Technical Details

Product Overview

Hexamidine Diisethionate is a cationic bis-isethionate salt widely recognized in the personal care industry for its exceptional antimicrobial and antifungal efficacy. With a molecular formula of C24H38N4O10S2 and a molecular weight of 606.71 g/mol, this compound demonstrates strong activity against Malassezia species—particularly Pityrosporum ovale (now classified as Malassezia furfur)—the primary microorganism associated with dandruff and seborrheic dermatitis. Its water-soluble nature and low irritation profile make it highly suitable for sensitive skin and ocular-area applications.

Specifications

Appearance	White powder or crystal
Assay	≥99% (Test result: 99.2%)
Odor	Weak
Melting Point	217–220°C (Test result: 218.0–218.8°C)
Loss on Drying	≤0.5% (Test result: 0.30%)
Isethionate Content	40.9–42.2% (Test result: 41.5%)
Hexamidine Base Content	57.5–59.3% (Test result: 58.5%)
Heavy Metals	≤10 ppm (Conforms)

Industrial Applications

As a high-performance cosmetic active ingredient, Hexamidine Diisethionate is primarily used in anti-dandruff shampoos, scalp treatments, and leave-on hair care products. It offers broad-spectrum activity against Gram-positive and Gram-negative bacteria, molds, and yeasts, while maintaining excellent compatibility with common surfactants and conditioning agents. Key advantages include:

Effective at low use concentrations (typically 0.1–0.5%)
Minimal skin, eye, and scalp irritation
Excellent formulation stability and resistance to discoloration
Synergistic with other actives like zinc pyrithione or climbazole

Its safety and efficacy are well-documented in dermatological studies, supporting its inclusion in over-the-counter (OTC) and premium cosmetic formulations worldwide.