Cosmetic Active Ingredients

Substance P

CAS No.33507-63-0
GradeIndustrial / Pharmaceutical
Availability● In Stock

Substance P is a bioactive neuropeptide widely studied for its role in skin physiology and neurocosmetic applications. Supplied as a high-purity (≥98.0%) white to off-white powder.

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Product Technical Details

Product Overview

Substance P is an endogenous undecapeptide belonging to the tachykinin family of neuropeptides. With the sequence RPKPQQFFGLM-NH2, it functions primarily as a neurotransmitter and neuromodulator in both central and peripheral nervous systems. In the field of cosmetic science, Substance P has garnered significant interest due to its involvement in cutaneous neurogenic inflammation, wound healing, and sensory perception pathways.

Specifications

Molecular Formula	C63H98N18O13S
Molecular Weight	1347.63 g/mol
Density	1.4 ± 0.1 g/cm³
Refractive Index	1.663
Appearance	White to off-white powder
Assay (Purity)	≥98.0%
Storage	Store in a cool, ventilated place
Packaging	25 kg/drum; custom packaging available upon request

Industrial Applications

In cosmetic formulations, Substance P is leveraged as a research-grade active ingredient to explore neurocosmetic mechanisms, particularly those related to skin barrier communication, stress-induced sensitivity, and epidermal regeneration. It interacts selectively with the neurokinin 1 receptor (NK1R), which is expressed in various skin cell types including keratinocytes and fibroblasts. This interaction makes it a valuable tool for developing advanced skincare products targeting neurogenic inflammation, redness, and sensory discomfort.

Serves as a key biomarker in dermatological and neurocosmetic R&D
Enables formulation scientists to study peptide-receptor dynamics in topical delivery systems
Supports innovation in 'smart' actives that modulate skin-neural crosstalk

As a globally supplied cosmetic active ingredient, our Substance P meets stringent quality standards and is accompanied by comprehensive documentation including Certificate of Analysis (COA) and safety data, ensuring seamless integration into professional cosmetic development pipelines.