1-Methyl-D-tryptophan: Potent IDO Inhibitor for Cancer and Immune Response Research
Explore the critical role of 1-Methyl-D-tryptophan in modulating immune responses and its potential in cancer immunotherapy.
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1-Methyl-D-tryptophan
1-Methyl-D-tryptophan (1-MT) is a highly effective inhibitor of indoleamine 2,3-dioxygenase (IDO) and IDO2, key enzymes in the kynurenine pathway. By disrupting tryptophan catabolism, 1-MT plays a significant role in modulating the immune system. It enhances the antitumor and antiviral immunoresponses mediated by CD8+ T-cells, making it a valuable agent in immuno-oncology and infectious disease research. Furthermore, studies indicate that 1-MT can reduce tumor volume in animal models, showcasing its therapeutic potential.
- Discover how 1-Methyl-D-tryptophan acts as a critical IDO inhibitor, crucial for understanding and manipulating immune checkpoint pathways.
- Leverage 1-MT for cancer immunotherapy research by enhancing the efficacy of CD8+ T-cells against neoplastic cells.
- Investigate the disruption of tryptophan catabolism with 1-Methyl-D-tryptophan to uncover new therapeutic strategies for inflammatory diseases.
- Explore the benefits of immune response modulation using 1-Methyl-D-tryptophan to improve outcomes in both cancer and antiviral treatments.
Key Product Advantages
Potent IDO Inhibition
1-Methyl-D-tryptophan provides robust inhibition of IDO and IDO2, essential for unlocking immune responses by preventing tryptophan depletion in the tumor microenvironment.
Enhanced Immune Cell Activity
Utilize 1-Methyl-D-tryptophan to boost the effectiveness of CD8+ T-cells, critical for mounting a strong antitumor and antiviral defense.
Preclinical Efficacy
Demonstrated ability to reduce tumor volume in xenograft models highlights the in vivo potential of 1-Methyl-D-tryptophan in cancer treatment strategies.
Key Applications
Cancer Immunotherapy
As an IDO inhibitor, 1-Methyl-D-tryptophan is instrumental in developing next-generation cancer immunotherapies aimed at overcoming immune suppression.
Antiviral Research
Its role in enhancing CD8+ T-cell responses makes 1-Methyl-D-tryptophan a key compound for research into novel antiviral treatments.
Inflammatory Disease Study
Investigating the kynurenine pathway with 1-Methyl-D-tryptophan can shed light on chronic inflammatory conditions and potential therapeutic interventions.
Immune Modulation Research
The compound serves as a vital tool for scientists studying broader immune system regulation and response mechanisms.