Intermediates

Isonicotinamide

  • CAS No.1453-82-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

Isonicotinamide is a high-purity pharmaceutical intermediate primarily used in the synthesis of antihistamines like Loratadine.

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Product Technical Details

Product Overview

Isonicotinamide represents a critical building block within the realm of pharmaceutical organic synthesis. As a derivative of pyridine, this compound features a carboxamide group at the fourth position of the aromatic ring, granting it unique reactivity profiles suitable for complex molecular construction. Our facility produces this material under strict quality control guidelines to ensure consistency across batches. This chemical is widely recognized in the industry for its stability and versatility in heterocyclic chemistry.

The compound serves as a versatile intermediate for chemists developing antihistamines and other therapeutic agents. Specifically, it acts as a key precursor in the synthesis of second-generation antihistamines. Its high purity level minimizes side reactions during downstream processing, thereby improving overall yield and reducing waste. We understand that reliability in the supply chain is paramount for large-scale production schedules. Consistency in molecular weight and structural integrity is maintained through advanced spectroscopic verification.

Technical Specifications

ParameterValue
CAS Number1453-82-3
Molecular FormulaC6H6N2O
Molecular Weight122.125
AppearanceWhite to off-white crystalline powder
Assay≥99.0%
Melting Point155-157 °C
Moisture≤0.5%
Density1.2±0.1 g/cm3
Boiling Point334.4±15.0 °C

Industrial Applications

From a structural perspective, the pyridine ring offers excellent thermal stability, which is crucial for reactions requiring elevated temperatures. The amide functionality allows for various derivatization pathways, enabling medicinal chemists to explore diverse chemical spaces. This flexibility makes the product invaluable for library synthesis in drug discovery programs. Furthermore, the low moisture content specification ensures that water-sensitive reactions can proceed without additional drying steps, saving time and resources.

Our commitment to quality extends beyond mere assay percentages. We perform comprehensive testing including moisture content analysis and residual solvent checks. Each shipment is accompanied by a Certificate of Analysis (COA) that verifies compliance with agreed-upon specifications. This documentation is essential for regulatory filings and internal audit processes. Our laboratory utilizes high-performance liquid chromatography to confirm the assay is greater than 99 percent.

Quality and Packaging

Packaging is designed to maintain integrity during international transit. Standard units are sealed in moisture-resistant drums, typically holding 25 kilograms per container. This protects the content from humidity and contamination. For clients with specific logistical needs, we offer flexible packaging solutions to accommodate various warehouse configurations. Custom labeling is available to meet import and export regulations.

Storage recommendations emphasize maintaining a cool and ventilated environment. Proper handling ensures that the chemical properties remain stable over extended periods. Our technical support team is available to provide guidance on safe handling procedures and integration into your specific synthesis routes. We advise keeping the container tightly closed when not in use to prevent moisture absorption.

Safety is a core component of our operational philosophy. While this compound is generally stable, standard laboratory precautions should be observed. We recommend using appropriate personal protective equipment during handling. Our safety data sheets are updated regularly to reflect the latest regulatory requirements. By adhering to these guidelines, facilities can maintain a safe working environment while leveraging the chemical benefits of this intermediate.

In summary, our Isonicotinamide provides a reliable foundation for pharmaceutical manufacturing. The combination of high purity, consistent quality, and robust supply chain management distinguishes our offering in the market. We invite potential partners to request samples for evaluation purposes. Our goal is to support your innovation through superior chemical ingredients. Contact our sales team for current bulk pricing and lead time information.